- Pd-catalyzed Suzuki/Sonogashira cross-coupling reaction and the direct sp3 arylation of 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine
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A rapid and efficient method is reported for the synthesis of the [1,2,4]triazolo[1,5-a]pyrimidine motif. Palladium catalyzed Suzuki and Sonogashira cross coupling reactions on 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine were performed. The direct sp3 arylation of compounds resulting from the Suzuki reaction was then carried out.
- Loubidi, Mohammed,Moutardier, Ana?s,Campos, Joana F.,Berteina-Raboin, Sabine
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Read Online
- On triazoles. XXXV. The reaction of 5-amino-1,2,4-triazoles with di- and triketones
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The reaction of 5-amino-3-Q-1H-1,2,4-triazoles 1 with aliphatic, aromatic and cyclic 1,3-diketones, 1,4-diketones, and different linear and non linear triketones was studied. It was proved that in case of unsymmetrical aliphatic 1,3-diketones the regiochemical outcome of the reaction was influenced by steric factors. In case of triacetylmethane and 3-(4-chlorobenzyl)-2,4-pontanedione the splitting of one acetyl group from the reactant was observed during the reaction. A liner triketone, namely the 2,4,6-trioxoheptane reacted as a simple 1,3-diketone.
- Reiter,Pongo,Kovesdi,Pallagi
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p. 407 - 417
(2007/10/02)
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- CHEMICAL CONVERSIONS OF 5,7-DISUBSTITUTED DIHYDRO-1,2,4-TRIAZOLOPYRIMIDINES
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Hydrolysis, oxidation, reduction, alkylation, and nitrosation of aromatic-substituted dihydro-1,2,4-triazolopyrimidines have been studied.
- Desenko, S. M.,Orlov, V. D.,Lipson, V. V.
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p. 1362 - 1366
(2007/10/02)
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