- Cationic lipid compound and its preparation method
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The invention discloses cationic lipid compounds and a preparation method thereof. The molecular structure general formula of the compounds is shown as the description, wherein R is alkyl groups of C6 to C24, alkylenes of C6 to C24 and acyl groups of C6 t
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Paragraph 0025; 0027
(2017/07/11)
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- Tuning the Thermo-Sensitivity of Micellar Systems through a Blending Approach
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This paper reports an original and easy route toward thermosensitive micelles based on a lipidic core and with adjustable cloud point temperatures (TCP) through a simple blending approach between two copolymers of different TCP. The cationic ring-opening polymerization (CROP) of various 2-alkyl-2-oxazoline monomers was first investigated from both mesylated and tosylated lipoinitiators and different lipid-b-poly(2-methyl-2-oxazoline), lipid-b-poly(2-ethyl-2-oxazoline), lipid-b-poly(2-isopropyl-2-oxazoline) and lipid-b-poly((2-ethyl-2-oxazoline)-co-(2-isopropyl-2-oxazoline)) copolymers were synthesized. Blending of lipid-b-p(EtOx) and lipid-b-p(iPrOx) copolymers in various proportions were then prepared and their TCP investigated through UV-visible spectroscopy. Very interesting results were obtained as the blends exhibit a single TCP ranging from 35 to 45 °C. Furthermore, the blends TCP correspond to those of the statistical lipid-b-p((EtOx)-co-(iPrOx)) for the same p(EtOx)/p(iPrOx) content up to 52 wt % of p(EtOx). The blending approach is then an attractive strategy to control the TCP of micellar systems through a simple and easy formulation approach rather than fastidious syntheses.
- El Asmar, Arlette,Gimello, Olinda,Morandi, Ga?lle,Le Cerf, Didier,Lapinte, Vincent,Burel, Fabrice
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p. 4307 - 4315
(2016/07/06)
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- Synthesis of phosphatidylcholine having a very long chain polyunsaturated fatty acid
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A phosphatidylcholine 9 bearing icosadienoyl and docosahexaenoyl groups at the 1-and 2-positions respectively was synthesized. The synthetic route involves carbon chain elongation of linoleic acid via malonic ester synthesis, preparation of lyso-phosphatidylcholine via lipase-catalyzed mono-acylation of 2-O-methoxyethoxymethylglycerol and phosphodiester synthesis, and finally DCC-mediated esterification.
- Haider, Syed Shabbir,Tanaka, Masatoshi,Alam, Md Khorshed,Nakajima, Shuhei,Baba, Naomichi,Shimizu, Sakayu
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p. 175 - 176
(2007/10/03)
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- Polyene Pheromone Components from an Arctiid Moth (Utetheisa ornatrix): Characterization and Synthesis
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In our earlier study of the female sex attractant from an arctiid moth (Utetheisa ornatrix), the occurence of an uncharacterized C-21 tetraene was noted along with (Z,Z,Z)-3,6,9-heneicosatriene, the major pheromone constituent.The sex attractant glands of females from other populations of this moth have now yielded this C-21 tetraene as a major component, accompanied by a new C-21 diene.Spectral and chemical studies of these two EAG-active compounds led to their characterization as (Z,Z,Z)-1,3,6,9-heneicosatetraene and (Z,Z)-6,9-heneicosadiene.These structures and configurations were confirmed by synthesis.
- Jain, Subhash C.,Dussourd, David E.,Conner, William E.,Eisner, Thomas,Guerrero, Angel,Meinwald, Jerrold
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p. 2266 - 2270
(2007/10/02)
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