- Minor structural modifications to Pracinostat produce big changes in its biological responses
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A series of compounds similar to Pracinostat that contained benzimidazole ring and N-hydroxyacrylamide attached at 5- or 6-position were designed, synthesized, and evaluated as HDAC inhibitors. It was interesting to find that the corresponding derivative 1 with N-hydroxyacrylamide attached at 5-position was a potent HDAC inhibitor while the others at 6-position were not. This is the first time to demonstrate the position difference plays important role in the HDAC inhibitory activities of the cinnamic hydroxamates.
- Jia, Rong,Sun, Pengju,Zhang, Yan,Ge, Youjin,Yu, Niefang
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p. 1488 - 1493
(2019/05/07)
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- Facile, environmentally friendly synthesis of benzaldehyde and phenylacetaldehyde analogs from readily available toluene derivatives
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A facile environmentally friendly synthesis of bezaldehyde and phenylacetaldehyde analogs from readily available toluene derivatives is described. Oxidation of the styrylamines by H2O2 H2O2 affords benzaldehydes in moderate yields, while the hydrolysis of styrylamines afforded phenylacetaldehyde analogs in good yields. Copyright
- Dai, Liyan,Yu, Jie,Chen, Yingqi,Yu, Shichao
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scheme or table
p. 3078 - 3084
(2011/09/14)
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- Synthesis, larvicidal activity, and SAR studies of new benzoylphenylureas containing oxime ether and oxime ester group
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A series of new structural benzoylphenylureas (BPUs) containing oxime ether and oxime ester group were designed and synthesized. The larvicidal activities against Oriental armyworm and mosquito of these benzoylphenylureas were evaluated and the result of bioassay displayed specific structure-activity relationship (SAR). Most of the compounds exhibited excellent larvicidal activities against Oriental armyworm and mosquito. Interestingly, some compounds showed different structure-activity relationship towards diamondback moth, beet armyworm, and corn borer although three tested insects all belong to the same insect order.
- Sun, Ranfeng,Li, Yongqiang,Lue, Maoyun,Xiong, Lixia,Wang, Qingmin
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supporting information; experimental part
p. 4693 - 4699
(2010/10/02)
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- para-Formylation of nitroarenes via vicarious nucleophilic substitution of hydrogen with tris(benzotriazol-1-yl)methane
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Reaction of nitroarenes 1 with tris(benzotriazol-1-yl)methyl 2 anion afforded para-bis(benzotriazol-1-yl)methylated products 3 which, upon treatment with zinc bromide and hydrochloric acid, yielded the corresponding p-nitroarylaldehydes 4 in good yields.
- Katritzky, Alan R.,Xie, Linghong
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p. 347 - 350
(2007/10/02)
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- Comparative Reactivity of Substituted 4-Nitrobenzylidene Dichlorides with Alkali
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A comparative study of the reactions of substituted 4-nitrobenzylidene dichlorides ArCHCl2 (Ar = 3-Cl-4-NO2C6H3, 2-Cl-4-NO2C6H3, 4-NO2C6H4, 3,5-Me2-4-NO2C6H2, and 2-Me-4-NO2C6H3) with aqueous alcoholic alkali shows that chlorine substitution enhances the
- Goh, Swee Hock,Kam, Toh Seok
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p. 423 - 426
(2007/10/02)
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