57507-34-3

Basic information

• Product Name: 3-CHLORO-4-NITROBENZALDEHYDE
• Synonyms: 3-CHLORO-4-NITROBENZALDEHYDE
• CAS NO: 57507-34-3
• Molecular Formula: C₇H₄ClNO₃
• Molecular Weight: 185.56456
• Product Categories: Aromatic Aldehydes & Derivatives (substituted)
• Mol File: 57507-34-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 327.5°C at 760 mmHg
• Flash Point: 151.9°C
• Appearance: /
• Density: 1.485g/cm³
• Vapor Pressure: 0.000201mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 3-CHLORO-4-NITROBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-NITROBENZALDEHYDE(57507-34-3)
• EPA Substance Registry System: 3-CHLORO-4-NITROBENZALDEHYDE(57507-34-3)

Safety Data

• Hazardous Substances Data: 57507-34-3(Hazardous Substances Data)

Usage

Description

3-Chloro-4-nitrobenzaldehyde is an organic compound that belongs to the class of aromatic aldehydes. It is characterized by the presence of a chlorine atom at the 3rd position and a nitro group at the 4th position on a benzene ring, with an aldehyde functional group attached to the carbon chain. 3-CHLORO-4-NITROBENZALDEHYDE is known for its reactivity and is widely utilized in the synthesis of various organic compounds.

Uses

Used in Synthetic Chemistry:
3-Chloro-4-nitrobenzaldehyde is used as a reagent for the synthetic preparation of [(pyridinyl)oxadiazolyl]ethanone derivatives. These derivatives are of significant interest due to their potential applications in various fields, including pharmaceuticals and materials science.
Used in Antioxidant Activity Determination:
The [(pyridinyl)oxadiazolyl]ethanone derivatives synthesized using 3-chloro-4-nitrobenzaldehyde are also evaluated for their antioxidant activity. Antioxidants play a crucial role in protecting cells from damage caused by reactive oxygen species, and the development of new, effective antioxidants is an ongoing area of research. By using 3-chloro-4-nitrobenzaldehyde as a reagent, chemists can synthesize and test new compounds for their potential antioxidant properties, contributing to the development of novel antioxidants for various applications.

InChI:InChI=1/C7H4ClNO3/c8-6-3-5(4-10)1-2-7(6)9(11)12/h1-4H

Upstream product

• 77455-53-9 Acetic acid acetoxy-(3-chloro-4-nitro-phenyl)-methyl ester 
• 39608-47-4 3-chloro-4-nitrobenzoic acid 
• 1321621-16-2 C₁₀H₁₁ClN₂O₂ 
• 38939-88-7 2-chloro-4-methyl-1-nitrobenzene 
• 88088-95-3 tris(benzotriazol-1-yl)methane 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 1400287-79-7 2-chloro-4-(1,4-dimethyl-1H-imidazol-5-yl)aniline 
• 1400287-78-6 5-(3-chloro-4-nitrophenyl)-1,4-dimethyl-1H-imidazole 
• 1400287-77-5 N-(3-chloro-4-nitrobenzylidene)methanamine 
• 1244060-77-2 3-chloro-4-nitrobenzaldehyde oxime 
• 1094554-39-8 C-1-[(3-chloro-4-nitrophenyl)methyl]-4-methylpiperazine 
• 77455-61-9 (E)-α,α',3,3'-tetrachloro-4,4'-dinitrostilbene 
• 77455-62-0 (Z)-α,α',3,3'-tetrachloro-4,4'-dinitrostilbene 
• 77455-60-8 1,2-bis-(3-chloro-4-nitrophenyl)tetrachloroethane 
• 77455-63-1 3,3'-dichloro-4,4'-dinitrodiphenylacetylene 
• 77455-59-5 3-chloro-4-nitrobenzyl chloride 
• 77455-58-4 3-chloro-4-nitrobenzylidene dichloride 

Relevant articles and documents

Minor structural modifications to Pracinostat produce big changes in its biological responses

A series of compounds similar to Pracinostat that contained benzimidazole ring and N-hydroxyacrylamide attached at 5- or 6-position were designed, synthesized, and evaluated as HDAC inhibitors. It was interesting to find that the corresponding derivative 1 with N-hydroxyacrylamide attached at 5-position was a potent HDAC inhibitor while the others at 6-position were not. This is the first time to demonstrate the position difference plays important role in the HDAC inhibitory activities of the cinnamic hydroxamates.

Synthesis, larvicidal activity, and SAR studies of new benzoylphenylureas containing oxime ether and oxime ester group

A series of new structural benzoylphenylureas (BPUs) containing oxime ether and oxime ester group were designed and synthesized. The larvicidal activities against Oriental armyworm and mosquito of these benzoylphenylureas were evaluated and the result of bioassay displayed specific structure-activity relationship (SAR). Most of the compounds exhibited excellent larvicidal activities against Oriental armyworm and mosquito. Interestingly, some compounds showed different structure-activity relationship towards diamondback moth, beet armyworm, and corn borer although three tested insects all belong to the same insect order.

Comparative Reactivity of Substituted 4-Nitrobenzylidene Dichlorides with Alkali

A comparative study of the reactions of substituted 4-nitrobenzylidene dichlorides ArCHCl2 (Ar = 3-Cl-4-NO2C6H3, 2-Cl-4-NO2C6H3, 4-NO2C6H4, 3,5-Me2-4-NO2C6H2, and 2-Me-4-NO2C6H3) with aqueous alcoholic alkali shows that chlorine substitution enhances the