Xanthines, optionally incorporated in liposomes, for promoting skin or hair pigmentation
A method of treating skin or hair for promoting pigmentation wherein a xanthine component, in an amount effective to promote pigmentation, is incorporated in liposomes or hydrated lipidic lamellar phases.
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(2008/06/13)
Synthesis, toxicological and pharmacological assessment of 7-substituted derivatives of 1,3-dimethylxanthine
The synthesis of two 7-substituted theophylline derivatives from the theophylline sodium salt, dichloroalkane and N-methyl-N-cyclohexylamine is reported. The structures of the synthesized compounds were proved by microanalyses and 1H-NMR data. Acute toxicity studies of the compounds were performed on mice and rats. A comparative pharmacological study of the in vivo broncholytic effect of the derivatives and aminophylline showed that the new compounds have different bronchodilatory activity and the compound 7-[2-(N-methyl-N-cyclohexyl)-aminoethyl]-1,3-dimethylxanthine tartrate 3a was more active than 7-[3-(N-methyl-N-cyclohexyl)-aminopropyl]-1,3-dimethylxanthine hydrochloride 3b. It was demonstrated that compound 3b and aminophylline exerted the strongest inhibitory effect on the enzyme activity of phosphodiesterase in lung homogenate. Compound 3a showed a slight inhibitory effect on the enzyme activity in this homogenate. The possible mechanisms of the broncholytic effects of these compounds are discussed.
Peikov,Zlatkov,Markov,Danchev,Ivanov,Panova
p. 295 - 299
(2007/10/02)
Amide derivatives and 5-lipoxygenase inhibitors containing the same as an active ingredient
According to the invention, there are provided novel amide derivatives and 5-lipoxygenase inhibitors containing the same as an effective ingredient. The above-mentioned compounds of the invention have been demonstrated to posses 5-lipoxygenase-inhibiting activities. These compounds can inhibit the production of leucotrienes such as LTC4 and LTD4 which are allergy-inducing factors by inhibiting the activity of 5-lipoxygenase. Accordingly, the amide derivatives can be used as 5-lipoxygenase inhibitors effective for allergic asthma, allergic rhinitis and the like.
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(2008/06/13)
A Procedure for the Preparation of N-(ω-Haloalkyl)xanthines Based on Phase-Transfer Catalysis
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Kalcheva, Veneta B.,Apostolova, Tatiana M.,Anakieva, Violeta Z.
p. 165 - 168
(2007/10/02)
Synthesis and pharmacological testing of some theophylline esters
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Ride,Farghaly,Ashour
p. 672 - 676
(2007/10/04)
Coenzyme model studies. I. Synthesis of 3-carbamoyl pyridinium salts containing nucleic acid bases and their equilibria and reaction rates with cyanide ion in the presence of polyelectrolytes.
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Okubo,Ise
p. 4031 - 4036
(2007/10/08)
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