cas 59160-29-1, N-(2,6-DIMETHYLPHENYLCARBAMOYLMETHYL)IMINODIACETIC ACID | Articles data ｜lookchem

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59160-29-1

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Evaluation of 99mTc-labeled iminodiacetic acid derivatives of substituted 2-aminopyrroles as hepatobiliary imaging agents in rats II.
The synthesis and biodistribution properties of 99mTc-labeled 5-substituted N-(3-cyano-4-methyl-2-pyrrylcarbamoylmethyl)iminodiacetic acids and a similar series of N1-methyl analogs are described. These compounds were compared with 99mTc-labeled N-(2,6-dimethylphenylcarbamoylmethyl)iminodiacetic acid for hepatobiliary activity in the rat. The effects of structural modifications on biological activity are also reported.
Graham,Dejuliis,Mattson,Sowell Sr.
p. 362 - 364
(1982)
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Determination of stability constants and acute toxicity of potential hepatotropic gadolinium complexes
Due to their high specificity for the hepatobiliary system, iminodiacetic acid derivatives are known to form a class of hepatobiliary agents. In this paper we present new hepatotropic gadolinium complexes to be used as potential MRI contrast agents. Derivatives of N-(2-phenylamine-2-oxoethyl)iminodiacetic acid are introduced as ligands into such complexes. In this way, we hope to achieve a valuable diagnostic tool for investigating of pathological changes in the liver. Stability constants of complexes were determined by potentiometric titration in 0.1 mol L-1 NaNO3 solution at 20.0 ± 0.1OC. Stability and selectivity constants were also determined for endogenous metal ions such as Cu2+, Ca2+, and Zn2+ with the use of SUPERQUAD computer program. Acute toxicity of new gadolinium complexes was assessed in mice and histopathology examinations were carried out.
Mikiciuk-Olasik, Elzbieta,Wojewoda, Emilia,Bilichowski, Ireneusz,Witczak, Malgorzata,Karwowski, Boleslaw,Wagrowska-Danilewicz, Malgorzata,Stasikowska, Olga
p. 119 - 127
(2011/08/05)

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Chemical Properties

Appearance/Colour :white crystalline powder
Melting Point: 210 °C (dec.)(lit.)
Boiling Point: 546.3 °C at 760 mmHg
Flash Point:284.2 °C
Density: 1.352 g/cm³
Vapor Pressure: 9.05E-13mmHg at 25°C
Refractive Index: 1.5110 (estimate)
Merck: 14,5483
PSA: 106.94000
LogP: 0.78610

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