- Novel high-activity diphenyl ketone photoinitiator and preparation method thereof
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The invention belongs to the field of photosensitive high polymer materials, and provides a novel high-activity diphenyl ketone photoinitiator. Two diphenyl ketone derivatives are synthesized into a novel diphenyl ketone photoinitiator through synthesis reaction, so that ultraviolet absorption wavelength and absorption peak area of the photoinitiator are increased, a utilization rate on ultraviolet light is increased, the photoinitiating activity is greatly improved, and range of application is increased. The invention provides a preparation method for the novel diphenyl ketone photoinitiator,and the preparation method is simple in reaction process, is gentle in reaction condition, is simple in post-treatment, and is easy to purify.
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Paragraph 0043; 0046
(2019/02/19)
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- MALONONITRILE OXIME ETHER COMPOUND AND USE THEREOF
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Disclosed is a malononitrile oxime ether compound having a novel structure as shown in the general formula I. Respective substituents in the general formula I as defined in the specification. The compound of the general formula I exhibits an excellent microbicidal activity, and can effectively prevent and treat plant diseases caused by bacteria and fungi. Also provided is a use of the compound of the general formula I as a microbicide in the agricultural and other fields.
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Paragraph 0092; 0093
(2019/01/04)
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- Enantioselective Synthesis of Indolines, Benzodihydrothiophenes, and Indanes by C?H Insertion of Donor/Donor Carbenes
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We employ a single catalyst/oxidant system to enable the asymmetric syntheses of indolines, benzodihydrothiophenes, and indanes by C?H insertion of donor/donor carbenes. This methodology enables the rapid construction of densely substituted five-membered rings that form the core of many drug targets and natural products. Furthermore, oxidation of hydrazones to the corresponding diazo compounds proceeds in situ, enabling a relatively facile one- or two-pot protocol in which isolation of potentially explosive diazo alkanes is avoided. Regioselectivity studies were performed to determine the impact of sterics and electronics in donor/donor metal carbene C?H insertions to form indolines. This methodology was applied to a variety of substrates in high yield, diastereomeric, and enantiomeric ratios and to the synthesis of a patented indane estrogen receptor agonist with anti-cancer activity.
- Souza, Lucas W.,Squitieri, Richard A.,Dimirjian, Christine A.,Hodur, Blanka M.,Nickerson, Leslie A.,Penrod, Corinne N.,Cordova, Jesus,Fettinger, James C.,Shaw, Jared T.
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supporting information
p. 15213 - 15216
(2018/10/31)
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- NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR
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The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
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Page/Page column 55
(2012/06/15)
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- New pyrazole derivatives having CRTh2 antagonistic behaviour
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The present invention relates to a compound of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.
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Page/Page column 35
(2012/06/05)
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- An expedient synthesis of poly-substituted 1-arylisoquinolines from δ-ketonitriles via indium-mediated Barbier reaction protocol
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We developed an efficient synthetic strategy of poly-substituted 1-arylisoquinolines via an indium-mediated Barbier type allylation from δ-ketonitriles. Initial attack of allylindium species occurred at the nitrile group selectively to form the enamine intermediate, which reacted with the ketone group intramolecularly to furnish the isoquinolines.
- Kim, Sung Hwan,Lee, Hyun Seung,Kim, Ko Hoon,Kim, Jae Nyoung
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body text
p. 6476 - 6479
(2011/02/23)
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- Imidazolylmethylbenzophenones as highly potent aromatase inhibitors
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Suppression of tumor and plasma estrogen levels by inhibition of aromatase is one of the most effective treatments for post-menopausal breast cancer patients. Starting from an easy, synthetically accessible, benzophenone scaffold, a new class of potent aromatase inhibitors was synthesized, endowed with high selectivity with respect to 17α-hydroxylase/17,20-lyase (CYP17). Compounds 1b and 1d proved to be among the most potent inhibitors described so far.
- Gobbi, Silvia,Cavalli, Andrea,Negri, Matthias,Schewe, Katarzyna E.,Belluti, Federica,Piazzi, Lorna,Hartmann, Rolf W.,Recanatini, Maurizio,Bisi, Alessandra
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p. 3420 - 3422
(2008/02/12)
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- Novel cyclic amide derivatives
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Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: wherein X represents an alkyl group, an aryl group, a heterocyclic group or the like; Q represents a group represented by —CH2—, —CO—, —O—, —CH(OR7)— or the like wherein R7 represents a hydrogen atom, an alkyl group or the like; n represents an integer of from 0 to 5; R1 and R2 each represent a hydrogen atom, an alkyl group or the like; B represents either of the following groups: wherein R3, R4, R5, and R6 each represent a hydrogen atom, a halogen atom, an alkoxyl group or the like; m represents 1 or 2; and the ring of: represents an aromatic heterocyclic ring.
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- Intramolecular addition of a hydroxyl to a N-acyliminium system. Application to the synthesis of isoindolo[2,1-a] [3,1]benzoxazine and isoindolo[1,2-c][2,4] benzoxazepine derivatives
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The titled compounds were prepared by the reaction of hydroxylated lactam (3a-c) or (10) with p-toluenesulfonic acid in dichloromethane. The ratio of diastereomeric mixtures (4b/5b (2/1) or 4c/5c (2/1) or 11/12 (5/1)) is discussed.
- Pigeon, Pascal,Sikoraiova, Jana,Marchalin, Stefan,Decroix, Bernard
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p. 129 - 138
(2007/10/03)
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- Synthesis of 11-Phenyl-6H-dibenzo[b,f][1,4]oxazocine and 11-Phenyl-6H-dibenzo[b,f][1,4]thiazocine 1
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A convenient synthesis of 11-phenyl-6H-dibenzo[b,f] [1,4]oxazocine 1 and the corresponding thiazocine 2 is described.
- Jorgensen, Michael R.,McCleland, Cedric W.,Taljaard, Benjamin
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p. 356 - 357
(2007/10/03)
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- Generation, Detection, and Reaction of Ammonium Ylides in Reactions of phenylcarbenes
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Generation of diphenylcarbene (DPC) bearing a 2-(N,N-dimethylamino)methyl group in CHCl3 produced (N,N-dimethylamino)phenylisoindolium chloride and dichlorocarbene, which was trapped by added cyclohexene, while DPC having a 2-(N,N-dimethylamino)ethyl grou
- Tomioka, Hideo,Yamada, Sumiyo,Hirai, Katsuyuki
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p. 1298 - 1302
(2007/10/02)
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- Heterocyclic amine, derivatives, their production and use
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A novel heterocyclic amine derivative of the general formula: STR1 wherein a ring A and a ring B stand independently for an optionally substituted benzene ring, Z° stands for O or S or STR2 stands for --CH2 --, X stands for O, S or NR1/su
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