Novel and efficient synthesis of substituted quinoline-1-oxides and the complex compounds SnL2Cl2 (L=2-aminoquinoline-1-oxides) with the aid of stannous chloride
A novel and efficient approach to the synthesis of substituted quinoline-1-oxides and the complex compounds SnL2Cl2 (L=2-aminoquinoline-1-oxides) was developed. The reaction has fancy selectivity when 3-(2-nitrophenyl)acrylonitriles were treated with the aid of SnCl 2 reagent under the same conditions. When R is -CN or -COOR′ the complex compounds SnL2Cl2 (L=2-aminoquinoline-1- oxides) were obtained. Whereas, when R is H or aryl another series of substituted quinoline-1-oxides were formed. The products have been screened for their anticancer activities.
Synthesis of Substituted 2-Aminoquinoline-1-oxides by Reductive Cyclization of Substituted 3-(2-Nitrophenyl)acrylonitriles
An approach to the class of 2-aminoquinoline-1-oxides is given based on reductive cyclization of appropriate substituted 3-(2-nitrophenyl)acrylonitriles.Thus, 2-nitrobenzylidene compounds 1a-d have been reductively cyclized by H2/PtO2 or H2/Pd-C under nor
Sicker, D.,Wilde, H.
p. 76 - 80
(2007/10/02)
More Articles about upstream products of 59387-82-5