- Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D3 markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription
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Twelve new analogues of 19-nor-1α,25-dihydroxyvitamin D3 (5-16) were prepared by convergent syntheses, employing the Wittig Horner reaction. The necessary Grundmann type ketones (45-48), possessing fixed configurations of the hydroxyl group at
- Grzywacz, Pawel,Chiellini, Grazia,Plum, Lori A.,Clagett-Dame, Margaret,Deluca, Hector F.
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- 2alpha-Methyl and 2beta-Methyl Analogs of 19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 and Their Uses
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This invention discloses 2α-methyl and 2β-methyl analogs of 19,26-dinor-1α,25-dihydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit in vitro biological activities evidencing use as an anti-cancer agent and for the treatm
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Page/Page column 19; 26
(2012/11/13)
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- 2-Methylene-(20S,25S)-19,26-Dinor-Vitamin D Analogs
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This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arrestin
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Page/Page column 4; 7
(2009/07/17)
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- 2-Methylene-(20S,25S)-19,27-Dinor-(22E)-Vitamin D Analogs
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This invention discloses 2-methylene-(20S,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity
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Page/Page column 4; 7
(2008/06/13)
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- 2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs
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This invention discloses 2-methylene-(20R,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20R,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity
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Page/Page column 4; 7
(2008/06/13)
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- VITAMIN D ANALOG - NEL, METHODS AND USES THEREOF
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Compounds of formula IA or IB are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups and R1 is selected from straight or branched chain alkyl groups having from 1 to 8 ca
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Page/Page column 10-11
(2008/06/13)
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- Synthesis and Reaction of Optically Active 2- and 3-Hydroxyalkylphosphonium Salts
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Epoxides were converted to the corresponding optically active 2- and 3-hydroxyalkylphosphonium salts by the reaction with triphenylphosphine and dibenzoyltartaric acid (or camphorsulfonic acid), and with methylenetriphenylphosphorane and this acid, follow
- Yamamoto, Shin-ichi,Takeuchi, Hiroshi,Tanaka, Yuichiro,Okuma, Kentaro
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p. 113 - 116
(2007/10/02)
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