59780-25-5Relevant articles and documents
Removal of the 26-methyl group from 19-nor-1α,25-dihydroxyvitamin D3 markedly reduces in vivo calcemic activity without altering in vitro VDR binding, HL-60 cell differentiation, and transcription
Grzywacz, Pawel,Chiellini, Grazia,Plum, Lori A.,Clagett-Dame, Margaret,Deluca, Hector F.
, p. 8642 - 8649 (2010)
Twelve new analogues of 19-nor-1α,25-dihydroxyvitamin D3 (5-16) were prepared by convergent syntheses, employing the Wittig Horner reaction. The necessary Grundmann type ketones (45-48), possessing fixed configurations of the hydroxyl group at
2-Methylene-(20S,25S)-19,26-Dinor-Vitamin D Analogs
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Page/Page column 4; 7, (2009/07/17)
This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arrestin
2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs
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Page/Page column 4; 7, (2008/06/13)
This invention discloses 2-methylene-(20R,25S)-19,27-dinor-(22E)-vitamin D analogs, and specifically 2-methylene-(20R,25S)-19,27-dinor-(22E)-1α,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity
