- Process for making 5-introbarbituric acid and salts thereof
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A process for preparing salts of 5-nitrobarbituric acid involves allowing an in situ generated a compound represented by formula (I): STR1 wherein R1 and R2 are the same or different and are, H, C1 to C8 alkyl or substituted C1 to C8 alkyl, aryl or substituted aryl, to condense with urea to obtain a condensation product; and neutralizing the condensation product with at least one organic base and another cation source (MX) at a pH≥7 and recovering the thus formed salt of 5-nitrobarbituric acid.
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- The Synthesis and Application of Novel Nitrating And Nitrosating Agents
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Alcohols and phenols are efficiently nitrated with thionyl chloride nitrate or thionyl nitrate, even in the presence of an aromatic moiety.While thionyl chloride nitrate is suitable for nitration of primary OH-groups in carbohydrates, thionyl nitrate is reactive enough to react with secondary OH-groups as well.These reagents permit the highly selective nitration of the 5'-, 2',5'- and 3',5'-OH-groups of ribonucleosides to produce either mono- or diprotected nitro derivatives in high yields.Carbon acids and the enol form of some ketones are efficiently nitrated with trifluoromethanesulfonyl nitrate/potassium tert-butoxide.Lutidine N-oxide(2,6-(CH3)2C5H3N->O) was found to have marked effect on nitration reactions.Similarly, thionyl chloride nitrite and thionyl nitrite exhibit an excellent capacity for nitrosation of the aforementioned substrates
- Hakimelahi, Gholam H.,Sharghi, Hashem,Zarrinmayeh, Hamide,Khalafi-Nezhad, Ali
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p. 906 - 915
(2007/10/02)
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