The Stereoselective Synthesis of 2-Alkyl γ-Keto Acid and Heterocyclic Ketomethylene Peptide Isostere Core Units Using Chiral Alkylation by 2-Triflyloxy Esters
A simple and general protocol for the enentioselective preparation of γ-keto acids and heterocyclic γ-keto acids which have an alkyl group at C-2 is reported.The alkyl group is introduced by chiral alkylation using a scalemic 2-triflyoxy ester.The alkylation takes place with inversion of configuration and is compatible with a variety of alkyl groups.This methodology is thus wellsuited for the preparation of a wide variety of ketomethylene peptide isosteres.
Hoffman, Robert V.,Kim, Hwa-Ok
p. 5107 - 5113
(2007/10/02)
CYCLODESHYDRATION DE DIOLS EN PRESENCE D'HMPT1
1,4 and 1,5-diols heated with 0.3 equivalent of HMPA undergo cyclodehydration leading to tetrahydrofurans and tetrahydropyrans.
Diab, J.,Abou-Assali, M.,Gervais, C.,Anker, D.
p. 1501 - 1502
(2007/10/02)
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