- Iodinated benzoyl acetals and ketals for x-ray imaging
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Compounds having the structure STR1 wherein (Z--COO is the residue of an iodinated aromatic acid; R is alkyl, cycloalkyl, aryl, aralkyl, STR2 or alkenyl; R1 is H, alkyl, cycloalkyl, aryl, aralkyl, or --CH2 --m CO2 R3 ; R2 is H, alkyl, cycloalkyl, aryl, aralkyl, --CH2 --n CO2 R4, or a STR3 group, wherein Z, R and R1 are as defined above; or R1 and R2, taken together with the carbon atom to which they are attached represent cycloalkyl; R3 is H, alkyl, cycloalkyl, aryl or aralkyl; R4 is H, alkyl, cycloalkyl, aryl or aralkyl; and m, n and p are independently an integer of from 0 to 17; provided that R1 and R2 can not both be H; are useful in the preparation of x-ray contrast compositions for medical imaging.
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- Iodinated aromatic propanedioates
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Compounds having the structure STR1 where (Z--COO is the residue of an iodinated aromatic acid; R1 and R2 are independently alkyl, fluoroalkyl, cycloalkyl, aryl or aralkyl; and R3 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, cyano, sulfonate, carboxamido, sulfonamido, CO2 -alkyl, CO2 -aryl or CO2 -aralkyl; are useful as contrast agents in x-ray imaging compositions and methods.
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- Radioactive functional diagnostic agents
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This invention relates to triiodized dicarboxylic acid anilides containing radioactive iodine of the formula SPC1 Wherein R1 is hydrogen, carboxyl, N-acylamino, N-acylaminomethyl, N-alkyl-N-acylamino, N-butyrolactamyl, or an EQU1 group, wherein R3 and R4 are each hydrogen, lower alkyl or hydroxyalkyl, or R3 and R4 together with the nitrogen atom form a 5 to 7 member heterocyclic ring which can contain a further oxygen, nitrogen or sulfur hetero atom; R2 is hydrogen, lower alkyl or hydroxyalkyl; and X is straight-chain or branched alkylene of 1-14 carbon atoms, which can be interrupted by one or more oxygen or sulfur atoms, As well as the physiologically acceptable salts thereof with suitable bases. These compounds are especially useful in the preparation of radioactive functional diagnostic agents.
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