Highly Efficient Nucleophilic Addition of Alkyl Grignard Reagents to 17-Ketosteroids in the Presence of Cerium(III)Chloride: Synthesis of 17α-Propyl-17β-Hydroxy-4-Androsten-3-one, An Androgen Receptor Antagonist
The addition of alkyl Grignard reagents to sterically hindered 17-ketosteroids was significantly enhanced by anhydrous cerium(III) chloride with notable suppression of abnormal reactions, while the addition products were obtained in good to excellent yields and high stereoselectivity.
Li, Xun,Singh, Shankar M.,Labrie, Fernand
p. 1157 - 1160
(2007/10/02)
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