60607-35-4 Usage
Description
Topterone, also known as 7α-methyl-17β-hydroxy-6-oxa-1,4,7,10-bisabolan-3-one, is a synthetic steroidal antiandrogen drug. It is a derivative of the bisabolane sesquiterpene class and exhibits potent antiandrogenic properties. Topterone is characterized by its unique structure, which includes a 6-oxa-1,4,7,10-bisabolan core and a 7α-methyl group, contributing to its effectiveness in blocking androgen receptors.
Uses
Used in Pharmaceutical Industry:
Topterone is used as a steroidal antiandrogen drug for the treatment of conditions associated with excessive androgen activity, such as prostate cancer and benign prostatic hyperplasia (BPH). Its ability to block androgen receptors helps in reducing the growth of androgen-sensitive tissues and alleviating symptoms related to androgen excess.
Used in Dermatological Applications:
Topterone is used as a therapeutic agent for acne treatment. Its antiandrogenic properties help in reducing the production of sebum, which is a major contributor to the development of acne. By inhibiting androgen receptors, topterone can effectively manage the inflammation and bacterial growth associated with acne.
Used in Hair Loss Treatment:
Topterone is used as a treatment for androgenic alopecia, commonly known as male pattern baldness. Its antiandrogenic effects help in reducing the impact of dihydrotestosterone (DHT), a hormone responsible for hair follicle miniaturization and hair loss. By blocking DHT receptors, topterone can promote hair growth and prevent further hair loss in individuals suffering from androgenic alopecia.
Check Digit Verification of cas no
The CAS Registry Mumber 60607-35-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,6,0 and 7 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 60607-35:
(7*6)+(6*0)+(5*6)+(4*0)+(3*7)+(2*3)+(1*5)=104
104 % 10 = 4
So 60607-35-4 is a valid CAS Registry Number.
InChI:InChI=1/C22H34O2/c1-4-10-22(24)13-9-19-17-6-5-15-14-16(23)7-11-20(15,2)18(17)8-12-21(19,22)3/h14,17-19,24H,4-13H2,1-3H3/t17?,18-,19-,20?,21?,22-/m0/s1
60607-35-4Relevant articles and documents
Highly Efficient Nucleophilic Addition of Alkyl Grignard Reagents to 17-Ketosteroids in the Presence of Cerium(III)Chloride: Synthesis of 17α-Propyl-17β-Hydroxy-4-Androsten-3-one, An Androgen Receptor Antagonist
Li, Xun,Singh, Shankar M.,Labrie, Fernand
, p. 1157 - 1160 (2007/10/02)
The addition of alkyl Grignard reagents to sterically hindered 17-ketosteroids was significantly enhanced by anhydrous cerium(III) chloride with notable suppression of abnormal reactions, while the addition products were obtained in good to excellent yields and high stereoselectivity.
