- Metal-free radical 5-exo-dig cyclizations of phenol-linked 1,6-enynes for the synthesis of carbonylated benzofurans
-
A new metal-free radical 5-exo-dig cyclization of phenol-linked 1,6-enynes with O2, 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO), and tBuONO is described. With this general method, carbonylated benzofurans can be accessed through incorporation
- Hu, Ming,Song, Ren-Jie,Li, Jin-Heng
-
-
Read Online
- Isobutyl Nitrite-Mediated Synthesis of Quinoxalines through Double C?H Bond Amination of N-Aryl Enamines
-
An efficient and metal-free double C?H bond amination of N-aryl enamines using isobutyl nitrite (IBN) has been developed. This method enables the preparation of functionalized quinoxalines in good to excellent yields and tolerates a variety of N-aryl enamines with diverse functional substituents. Mechanistic studies revealed the presence of a key β-imino oxime ester intermediate. A quinoxaline derivative could be prepared from β-carbonyl ester in one-pot sequence on a gram scale. Finally, two important quinoxaline scaffolds were easily prepared in moderate yields over two steps. (Figure presented.).
- Jiao, Yan-Xiao,Wei, Lin-Su,Zhao, Chun-Yang,Wei, Kai,Mo, Dong-Liang,Pan, Cheng-Xue,Su, Gui-Fa
-
p. 4446 - 4451
(2018/10/20)
-
- Potassium Iodide/tert-Butyl Hydroperoxide-Mediated Oxidative Annulation for the Selective Synthesis of N-Substituted 1,2,3-Benzotriazine-4(3H)-ones Using Nitromethane as the Nitrogen Synthon
-
A novel and efficient oxidative annulation of 2-aminobenzamides with nitromethane has been developed for the chemoselective synthesis of N-substituted 1,2,3-benzotriazine-4(3H)-ones in moderate to excellent yields under transition metal-free conditions. T
- Yan, Yizhe,Niu, Bin,Xu, Kun,Yu, Jianhua,Zhi, Huanhuan,Liu, Yanqi
-
supporting information
p. 212 - 217
(2016/02/14)
-
- Reactions of trifluoroamine oxide: A route to acyclic and cyclic fluoroamines and N-nitrosoamines
-
Acyclic secondary fluoroamines and N-nitrosoamines R2NF and R2NNO (R = CH3, C2H5, n-C3H7, i-C3H7, n-C4H9, i-C4H9, c-C6H11) and saturated nonaromatic heterocyclic fluoroamines and N-nitrosoamines R NF and R NNO [R = c-C4H8, c-C5H10, 2,6-(CH3)2-c-C5H8, 2,2,6,6-(CH3)4-c-C5H6] were prepared by reacting trifluoroamine oxide (NF3O) with the respective amine at ≤0 °C in a 1:2 molar ratio. The amine hydrofluoride salts are also formed. Trifluoroamine oxide is a very effective fluorinating and nitrosating reagent and provides an excellent route to >NF- and >NNO-containing compounds. With PF5, 2,2,6,6-(CH3)4-c-C5H6NFgave [CH2CH2CH2C(CH3)2N +=C(CH3)2]PF6-.
- Gupta, Om Dutt,Kirchmeier, Robert L.,Shreeve, Jean'ne M.
-
p. 2383 - 2386
(2007/10/02)
-
