- A 4 + 4 strategy for synthesis of zeolitic metal-organic frameworks: An indium-MOF with SOD topology as a light-harvesting antenna
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A zeolitic metal-organic framework with a SOD topology, (Et 2NH2)[In(BCBAIP)]·4DEF·4EtOH (H 4BCBAIP: 5-(bis(4-carboxybenzyl)amino)isophthalic acid) (1), has been constructed by a 4 + 4 synthetic strategy from tetrahedral organic building units and In3+ ions. Compound 1 could adsorb organic dyes and be used as a light-harvesting antenna.
- Sun, Libo,Xing, Hongzhu,Liang, Zhiqiang,Yu, Jihong,Xu, Ruren
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p. 11155 - 11157
(2013/11/19)
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- Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues
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New compounds derived from inhibitors of histone deacetylases (HDACs) have been synthesized and their antiproliferative activities towards non small lung cancer cell line H661 evaluated. Their design is based on hybrids between indanones to limit conformational mobility and other known HDAC inhibitors (SAHA, MS-275). The synthesis of these new derivatives was achieved by alkylation of appropriate indanones to introduce the side chain bearing a terminal ester group, the latter being a precursor of hydroxamic acid and aminobenzamide derivatives. These new analogues were found to be moderately active to inhibit H661 cell proliferation.
- Charrier, Cedric,Roche, Joelle,Gesson, Jean-Pierre,Bertrand, Philippe
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p. 6142 - 6146
(2008/03/14)
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- Vitamin d analogues
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Compounds of the formula I wherein X represents hydrogen or hydroxy; R1 and R2, which may be the same or different, represent hydrogen, (C1-C4)alkyl optionally substituted with one hydroxyl group or one or more fluorine atoms, or, together with the carbon atom to which they are attached, R1 and R2 form a (C3-C5)carbocyclic ring; R3 represents (C1-C4)alkyl, (C1-C4)alkoxy or a halogen atom, such as fluorine, chlorine, bromine, or iodine, and in-vivo hydrolyzable esters thereof with pharmaceutically acceptable acids, may be used in the prophylaxis and/or treatment of dieases characterized by abnormal cell differentiation and/or cell proliferation.
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- Macrocyclic Hydrocarbons with Rigid and Flexible Building Blocks
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We report the synthesis of a series of new hydrocarbon macrocycles. Following the dithia-phane route, four large rings 3-6 of the cyclophane type containing different numbers of ring atoms were prepared confirming the general applicability of this route compared to alternative macrocyclizations. Cycle 3 is the hydrocarbon analogue to the tetralactam and the sulfone amide macrocycles 1 and 2 used in many rotaxane syntheses. The macrocycles synthesized here are supposed to be uselful as wheels in the slipping approach to rotaxanes to further establish a reference system for the cavity size of cyclic compounds by comparing them to certain complemenatry blocking groups. The x-ray data obtained of the macrocycles 3, 5, and 6 reveal the cavity shape and size in solid state.
- Windisch,Voì?gtle,Nieger,Lahtinen,Rissanen
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p. 642 - 653
(2007/10/03)
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- Synthesis and structure-activity relationships of stilbene retinoid analogs substituted with heteroaromatic carboxylic acids
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Retinoids elicit biological responses by activating a series of nuclear receptors. Six retinoid receptors belonging to two families are currently known: retinoic acid receptors (RAR(α,β,andγ)) and retinoid X receptors (RXR(α,β,andγ)). Stilbene retinoid an
- Beard,Chandraratna,Colon,Gillett,Henry,Marler,Song,Denys,Garst,Arefieg,Klein,Gil,Wheeler,Kochhar,Davies
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p. 2820 - 2829
(2007/10/02)
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