- Subtype-selective N-methyl-D-aspartate receptor antagonists: Benzimidazalone and hydantoin as phenol replacements
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Previous work in our laboratories investigating compounds with structural similarity to ifenprodil (5) and 6 (CP101,606) resulted in compound 7 as a potent and selective antagonist of the NR1/2B subtype of the NMDA receptors. Replacement of the phenol gro
- Schelkun,Yuen,Serpa,Meltzer,Wise,Whittemore,Woodward
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p. 1892 - 1897
(2007/10/03)
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- 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
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Novel 1-[(heterocyclyl)alkyl]-4-diarylmethoxy piperidine derivatives are disclosed having the formula STR1 where n is 2-6, Ar1 and Ar2 are aryl and B is a substituted benzimidazolyl radical. These compounds are useful for their antianaphylactic and antihistaminic properties. Specific claimed compounds are 1-{3-[4-(diphenylmethoxy)-1-piperidinyl]-propyl}-1,3-dihydro-2H-benzimidazol-2-one, 1-{2-[4-(diphenylmethoxy)-1-piperidinyl]ethyl}1-, 3-dihydro-2H-benzimidazol-2-one, and 1-{4-[4-(diphenylmethoxy)-1-piperidinyl]butyl}-1,3-dihydro-2H-benzimidazol-2-one.
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- 1-Benzazolylalkyl-4-substituted-piperidines
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Compounds of the class of 1-(benzazolyalkyl)piperidine derivatives, useful as neuroleptic agents.
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