HIGHLY STEREOSELECTIVE PROCEDURE FOR (6R)-TETRAHYDROBIOPTERIN COFACTOR
(6R)-Tetrahydrobiopterin cofactor for aromatic amino acid hydroxylases was synthesized stereoselectively by catalytic hydrogenation of biopterin over platinum oxide at pH 11.4 and subsequent crystallization from hydrochloric acid and ethanol.
PROCESSES FOR PREPARING TETRAHYDROBIOPTERIN, AND ANALOGS OF TETRAHYDROBIOPTERIN
Process for the preparation of tetrahydrobiopterin from neopterin and/or 6-substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.
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(2008/06/13)
HYDROGENATION OF BIOPTERIN AND ITS ANALOGUES; APPLICATION FOR THE CONVENIENT PROCEDURE OF BIOPTERIN COFACTOR AND RELATED 5,6,7,8-TETRAHYDROPTERINS
A large scale and stereoselective hydrogenation of biopterin to (6R)-5,6,7,8-tetrahydrobiopterin was developed.The procedure was applied for various hydroxyalkylpterins such as neopterin and diastereomers of biopterin.