- Selenium-containing compounds and their use in treatment of neuro-degenerative diseases
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The present invention relates to compounds of Formula I or pharmaceutically acceptable salts, solvates or pro-drugs thereof. The invention also relates to a preparation method of the compound or the pharmaceutically acceptable salt, solvate or prodrug thereof, a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt, solvate or prodrug thereof and application ofthe compound or the pharmaceutically acceptable salt, solvate or prodrug thereof in preparation of drugs. The drugs are used for treating neuro-degenerative diseases.
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Paragraph 0089; 0097-0099
(2020/12/30)
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- Formation of dimer radical cations of selenourea on oxidation: Pulse radiolysis studies
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Reactions of oxidizing radicals like hydroxyl (·OH) radical, specific electron transfer agents like N?3, and I2-. radicals were studied with selenourea (SeU) and compared with thiourea (ThU) using pulse radiolysis technique in microsecond time scales. Both the compounds efficiently react with ·OH radicals, however, SeU undergoes easier oxidation by secondary oxidants as compared to ThU. The results were supported by cyclic voltammetry studies. The radical cations of both SeU and ThU formed on oxidation undergo dimerization with the parent molecule to form two-centered three-electron-hemi bonded radical cations absorbing at 410 and 400 nm respectively with the stabilization energies of 21.1 and 20.5 kcal/mol for SeU and ThU, respectively. Preliminary studies indicated that at low concentration of SeU, the dimerization is prevented and the oxidation reaction produced metallic Se nanoparticles. Copyright Taylor & Francis Inc.
- Indira Priyadarsini,Mishra,Maity,Mohan, Hari
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p. 985 - 988
(2007/10/03)
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- Synthesis of 1,3-selenazoles and bis(selenazoles) from primary selenocarboxylic amides and selenourea
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The reaction of nitriles with P2Se5 in the presence of EtOH-H2O afforded primary selenocarboxylic amides. The cyclization of these compounds with α-halo ketones afforded a variety of functionalized 1,3-selenazoles. The use of P2Se5 also allowed the convenient synthesis of selenocarboxylic diamides which were transformed into bis(selenazol-2-yl)alkanes ('bis-selenazoles'). A practical method for the synthesis of selenourea was developed. This useful small building block was successfully applied to the synthesis of primary 2-amino-1,3- selenazoles.
- Geisler, Karlheinz,Pfeiffer, Wolf-Diethard,Kuenzler, Andreas,Below, Harald,Bulka, Ehrenfried,Langer, Peter
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p. 875 - 884
(2007/10/03)
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- Efficient synthesis of primary selenocarboxylic amides by reaction of nitriles with phosphorous(V) selenide
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The reaction of nitriles with P2Se5 in the presence of EtOH/H2O afforded a variety of primary selenocarboxylic amides.
- Geisler, Karlheinz,Jacobs, Anke,Künzler, Andreas,Mathes, Manuela,Girrleit, Ilona,Zimmermann, Birgit,Bulka, Ehrenfried,Pfeiffer, Wolf-Diethard,Langer, Peter
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p. 1983 - 1986
(2007/10/03)
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