- Supramolecular synthesis of selenazoles using selenourea in water in the presence of β-cyclodextrin under atmospheric pressure
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Selenazoles were synthesized from α-bromo ketones and selenourea in the presence of β-cyclodextrin in water at 50 °C under atmospheric pressure.
- Narender,Reddy, M. Somi,Kumar, V. Pavan,Reddy, V. Prakash,Nageswar,Rao, K. Rama
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- A convenient synthesis of 2-amino-1,3-selenazoles using ionic liquids and microwave irradiation
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A simple and environmentally benign synthesis of 2-amino-1,3-selenazoles by microwave irradiation using 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF4) ionic liquid (IL) is described. Acyl halides, phenacyl halides, and-bromo-keto est
- Maradolla, Mohanbabu,Chandramouli
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- Selenazole diphosphonic acid compound and preparation method thereof
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The invention belongs to the technical field of medicines, and discloses a selenazole diphosphonic acid compound and a preparation method thereof, the structural characteristics of the compound are identified, the selenazole diphosphonic acid compound has
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Paragraph 0021
(2021/01/15)
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- Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors
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A series of novel aminopyrimidine and diaminopyrimidine derivatives were designed and optimized to improve their potency and permeability relative to lead compound 1 (IC50?=?37.4?μM), which was discovered in a previous virtual screening. The po
- Xu, Xiufeng,Peng,Wang, Junjie,Xu, Fengrong,Liang, Lei,Wang, Chao,Niu, Yan,Xu, Ping
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p. 926 - 933
(2019/02/19)
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- Green approach: An efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation
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An efficient and rapid procedure for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles has been described by the reaction of α-bromoketones with thiourea, phenylthiourea and selenourea at ambient temperature in aqueous medium under ultrasonic irradiation. Analytically pure products were formed within 10-60 s in excellent yields. The advantageous features of this non-conventional methodology over conventional methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild reaction conditions and no by-product production.
- Ramesh, Gondru,Janardhan, Banothu,Rajitha, Bavantula
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p. 8099 - 8109
(2015/04/16)
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- Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature
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Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4-disubstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-(2-bromoacetyl)-2H-chromen-2-one and thiourea/ phenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1-3 min in excellent yields.
- Banothu, Janardhan,Vaarla, Krishnaiah,Bavantula, Rajitha,Crooks, Peter A.
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p. 172 - 175
(2014/02/14)
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- A tandem one-pot aqueous phase synthesis of thiazoles/selenazoles
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The first ever tandem one-pot synthetic protocol for the synthesis of thiazoles/selenazoles from alkynes via the formation of 2,2-dibromo-1- phenylethanone is reported. The reaction is catalyzed by β-cyclodextrin in aqueous medium and resulted in good yields.
- Madhav,Narayana Murthy,Anil Kumar,Ramesh,Nageswar
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p. 3835 - 3838
(2012/08/14)
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- Solid-state synthesis of 1,3-selenazoles employing CuPy2Cl 2 as a Lewis acid catalyst
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1,3-Selenazoles were Synthesized from 3-bromo acetyl coumarin and selenourea in the presence of CuPy2Cl2 under solvent-free conditions at ambient temperature. The pure products were identified by spectral data. Copyright Taylor & Francis Group, LLC.
- Madhav, J. Venu,Kuarm, B. Suresh,Rajitha
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p. 3514 - 3522
(2008/12/23)
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- Synthesis of 1,3-selenazoles and bis(selenazoles) from primary selenocarboxylic amides and selenourea
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The reaction of nitriles with P2Se5 in the presence of EtOH-H2O afforded primary selenocarboxylic amides. The cyclization of these compounds with α-halo ketones afforded a variety of functionalized 1,3-selenazoles. The use of P2Se5 also allowed the convenient synthesis of selenocarboxylic diamides which were transformed into bis(selenazol-2-yl)alkanes ('bis-selenazoles'). A practical method for the synthesis of selenourea was developed. This useful small building block was successfully applied to the synthesis of primary 2-amino-1,3- selenazoles.
- Geisler, Karlheinz,Pfeiffer, Wolf-Diethard,Kuenzler, Andreas,Below, Harald,Bulka, Ehrenfried,Langer, Peter
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p. 875 - 884
(2007/10/03)
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- Synthesis and Reactivity of 2-Acyl-1,3-selenazoles
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2-Acyl-1,3-selenazoles were prepared in two steps from α- bromoketones and seleno amides. The base mediated fragmentation of these compounds afforded 2-unsubstituted 1,3-selenazoles. The reaction of 2-acyl-1,3-selenazoles with hydroxylamine hydrochloride
- Geisler, Karlheinz,Künzler, Andreas,Below, Harald,Bulka, Ehrenfried,Pfeiffer, Wolf-Diethard,Langer, Peter
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- Efficient synthesis of primary selenocarboxylic amides by reaction of nitriles with phosphorous(V) selenide
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The reaction of nitriles with P2Se5 in the presence of EtOH/H2O afforded a variety of primary selenocarboxylic amides.
- Geisler, Karlheinz,Jacobs, Anke,Künzler, Andreas,Mathes, Manuela,Girrleit, Ilona,Zimmermann, Birgit,Bulka, Ehrenfried,Pfeiffer, Wolf-Diethard,Langer, Peter
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p. 1983 - 1986
(2007/10/03)
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