- Synthetic method of VEGFR inhibitor furoquitinib and benzofuran intermediate thereof
-
The invention discloses a synthetic method of a VEGFR inhibitor furoquitinib and a benzofuran intermediate thereof. The synthetic method of the VEGFR inhibitor furoquitinib comprises the following steps of S1, halogenation, S2, acylation, S3, coupling, S4
- -
-
-
- METHODS OF PREPARING A VEGF-R INHIBITOR
-
The present invention relates to methods for preparing a compound of formula (7), which is useful as a modulator and/or inhibitor of protein kinases. The present invention also relates to intermediate compounds useful in the preparation of a compound of f
- -
-
Page/Page column 25
(2010/11/27)
-
- NOVEL QUINOLINE DERIVATIVES
-
The invention relates to compounds represented by Formula (I): and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R3-8, X3, X5, m, and n are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).
- -
-
Page/Page column 51
(2008/06/13)
-
- Benzofused heterozryl amide derivatives of thienopyridines useful as therapeutic agents, pharmaceutical compositions including the same, and methods for their use
-
The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
- -
-
-
- BENZOFUSED HETEROARYL AMIDE DERIVATIVES OF THIENOPYRIDINES USEFUL AS THERAPEUTIC AGENTS, PHARMACEUTICAL COMPOSITIONS INCLUDING THE SAME, AND METHODS FOR THEIR USE
-
The invention relates to compounds represented by the formula I and to prodrugs or metabolites thereof, or pharmaceutically acceptable salts or solvates of said compounds, said prodrugs, and said metabolites, wherein Z, Y, R11 and R14, R15, R16, and R17 are as defined herein. The invention also relates to pharmaceutical compositions containing the compounds of formula I and to methods of treating hyperproliferative disorders in a mammal by administering the compounds of formula I.
- -
-
-