A general and efficient method for the preparation of β-enamino ketones and esters catalyzed by indium tribromide
A variety of β-enamino ketones and esters have been synthesized in high to exellent yields by reacting β-dicarbonyl compounds with amines in the presence of a catalytic amount of indium tribromide. The reaction proceeds smoothly at room temperature in a short reaction time under solvent-free conditions.
Zhang, Zhan-Hui,Yin, Liang,Wang, Yong-Mei
p. 184 - 190
(2007/10/03)
Synthesis and biological screening of some new novel indole derivatives
Synthesis of some novel indole derivatives has been undertaken by the reaction of 1,4-benzoquinone with ethyl-β-(arylamino)-crotonates in the presence/absence of nitrogen atmosphere. The products 1a-o have been screened for their antimicrobial activity an
Mehta,Sikotra,Shah
p. 2594 - 2597
(2007/10/03)
SYNTHESIS OF SUBSTITUTED QUINOLINES BY REACTION OF THE VILSMEIER REAGENT WITH ANILINOBUTENOATES
The synthesis of substituted quinolines by the reaction of the Vilsmeier reagent prepared from phosphorus oxychloride and dimethylformamide with anilinobutenoates is reported.A plausible mechanism for the formation of the quinolines is suggested.
Adams, David,Dominguez, Jose,Russo, Vicente Lo,Rekowski, Norma Morante De
p. 281 - 284
(2007/10/02)
SYNTHESIS OF QUINOLINES BY REACTION OF ANILINOBUTENOATES WITH VILSMEIER REAGENT
The synthesis of substituted carboethoxyquinolines is described by the reaction of ethylanilinobutenoates with Vilsmeier reagent.
Adams, David R.,Dominguez, Jose N.,Perez, Julio A.
p. 517 - 518
(2007/10/02)
Synthesis and antitumor properties of bis (quinaldine) derivatives
A series of 7-nitro. and amino-N,N'-bis(4-quinaldinyl)-αω-diaminoalkanes related to the 6-amino derivative was synthezied and tested in the mouse P-388 lymphocytic leukemia screen. Three of the 7-nitro derivatives were found to have moderate activity (T/C 140-150%), while other nitro derivatives were devoid of any antitumor properties. All five 7-amino compounds were moderately to strongly active (T/C 134-196%). In addition, binding of amino derivatives 2-6 to DNA was examined by their ability to (1) stabilize DNA to thermal denaturation and (2) inhibit the DNA-dependent RNA polymerase reaction in vitro. T(m) data suggest that these compounds bind to DNA and are strong inhibitors of the polymerase reaction (I50 = 6-9 X 10-6 M).
Sinha,Philen,Sato,Cysyk
p. 1528 - 1531
(2007/10/04)
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