64334-94-7Relevant articles and documents
A general and efficient method for the preparation of β-enamino ketones and esters catalyzed by indium tribromide
Zhang, Zhan-Hui,Yin, Liang,Wang, Yong-Mei
, p. 184 - 190 (2007/10/03)
A variety of β-enamino ketones and esters have been synthesized in high to exellent yields by reacting β-dicarbonyl compounds with amines in the presence of a catalytic amount of indium tribromide. The reaction proceeds smoothly at room temperature in a short reaction time under solvent-free conditions.
SYNTHESIS OF SUBSTITUTED QUINOLINES BY REACTION OF THE VILSMEIER REAGENT WITH ANILINOBUTENOATES
Adams, David,Dominguez, Jose,Russo, Vicente Lo,Rekowski, Norma Morante De
, p. 281 - 284 (2007/10/02)
The synthesis of substituted quinolines by the reaction of the Vilsmeier reagent prepared from phosphorus oxychloride and dimethylformamide with anilinobutenoates is reported.A plausible mechanism for the formation of the quinolines is suggested.
Synthesis and antitumor properties of bis (quinaldine) derivatives
Sinha,Philen,Sato,Cysyk
, p. 1528 - 1531 (2007/10/04)
A series of 7-nitro. and amino-N,N'-bis(4-quinaldinyl)-αω-diaminoalkanes related to the 6-amino derivative was synthezied and tested in the mouse P-388 lymphocytic leukemia screen. Three of the 7-nitro derivatives were found to have moderate activity (T/C 140-150%), while other nitro derivatives were devoid of any antitumor properties. All five 7-amino compounds were moderately to strongly active (T/C 134-196%). In addition, binding of amino derivatives 2-6 to DNA was examined by their ability to (1) stabilize DNA to thermal denaturation and (2) inhibit the DNA-dependent RNA polymerase reaction in vitro. T(m) data suggest that these compounds bind to DNA and are strong inhibitors of the polymerase reaction (I50 = 6-9 X 10-6 M).
