- Method for preparing pharmaceutical intermediate of tryptophan derivative
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The synthesis method comprises the following steps: L - tryptophan derivatives are taken as starting materials, and esterification is carried out in sequence. The amidation, Boc protection, hydrolysis, amidation or sequential esterification, amidation, Boc protection, hydrogenation, hydrolysis, amidation yields a target product, a tryptophan derivative pharmaceutical intermediate. The preparation method has the advantages of cheap and easily available raw materials, environment friendliness, less process three wastes, accords with the idea of green pharmacy, mild reaction conditions, simple process, simple and convenient operation, high yield and purity and easy amplification and production.
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Paragraph 0086; 0088; 0099-0102
(2021/09/21)
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- Orthogonal protecting groups in the synthesis of tryptophanyl- hexahydropyrroloindoles
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The synthesis of various polycyclic systems containing aC 3a-Ni bond between a hexahydropyrrolo[2,3-b]indole and an indole tryptophan is described here. A series of experiments were performed to determine the best combination of five orthogonal protecting groups and the best reaction conditions for formation of said bond, which is a common feature among many recently discovered marine natural products.
- Ruiz-Sanchis, Pau,Savina, Svetlana A.,Acosta, Gerardo A.,Albericio, Fernando,Alvarez, Mercedes
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supporting information; experimental part
p. 67 - 73
(2012/01/15)
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- Copper-catalyzed cyclization of lodo-tryptophans: A straightforward synthesis of pyrroloindoles
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(Chemical Equation Presented) Pyrroloindoles are a key structural motif found in a wide number of biologically active alkaloids. Intramolecular copper-catalyzed coupling of readily accessible 2-iodo-tryptophan derivatives occurs in excellent yield, afford
- Coste, Alexis,Toumi, Mathieu,Wright, Karen,Razafimahaleo, Vanessa,Couty, Francois,Marrot, Jerome,Evano, Gwilherm
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supporting information; experimental part
p. 3841 - 3844
(2009/07/01)
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- A rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo[2,3-b]indole skeleton, a building block for 10b-hydroxypyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-diones
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A study was performed on the rapid stereocontrolled synthesis of the 3a-hydroxy-pyrrolo-[2,3-b]indole skeleton. A two-step selenocyclisation-oxidative deselenation sequence was used for the synthesis. It is reported that many biologically active natural products are based on this structure, such as the sporidesmins and certain members of the brevianamide and okaramine families.
- Ley, Steven V.,Cleator, Ed,Hewitt, Peter R.
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p. 3492 - 3494
(2007/10/03)
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