643751-42-2

Basic information

• Product Name: N-carbobenzyloxy-1-tert-butoxycarbonyl-L-tryptophan methyl ester
• Synonyms: N-carbobenzyloxy-1-tert-butoxycarbonyl-L-tryptophan methyl ester
• CAS NO: 643751-42-2
• Molecular Weight: 452.507
• Mol File: 643751-42-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-carbobenzyloxy-1-tert-butoxycarbonyl-L-tryptophan methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-carbobenzyloxy-1-tert-butoxycarbonyl-L-tryptophan methyl ester(643751-42-2)
• EPA Substance Registry System: N-carbobenzyloxy-1-tert-butoxycarbonyl-L-tryptophan methyl ester(643751-42-2)

Safety Data

• Hazardous Substances Data: 643751-42-2(Hazardous Substances Data)

Upstream product

• 4299-70-1 L-tryptophan methyl ester 
• 73-22-3 L-Tryptophan 
• 501-53-1 benzyl chloroformate 
• 7524-52-9 (S)-tryptophan methyl ester hydrochloride 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2717-76-2 (S)-N-benzyloxycarbonyl-L-tryptophan methyl ester 

Downstream Products

• 1356557-62-4 exo-methyl 1-benzyloxycarbonyl-3a-bromo-8-tert-butyloxycarbonyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylate 
• 146645-63-8 (2S)-2-amino-3-(1-tert-butoxycarbonylindol-3-yl)propanoic acid 
• 143824-78-6 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester 
• 131829-26-0 (S)-2-(((benzyloxy)carbonyl)amino)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid 
• 1054604-07-7 (2S,3aR,8aS)-1-((S)-1-Benzyloxycarbonyl-pyrrolidine-2-carbonyl)-3a-hydroxy-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole-2-carboxylic acid methyl ester 
• 1054630-85-1 (2S,3aR,8aS)-1-((S)-2-Benzyloxycarbonylamino-3-hydroxy-propionyl)-3a-hydroxy-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole-2-carboxylic acid methyl ester 
• 1053740-72-9 (2S,3aR,8aS)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyryl)-3a-hydroxy-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole-2-carboxylic acid methyl ester 
• 1054626-88-8 (2S,3aR,8aS)-1-((S)-2-Benzyloxycarbonylamino-propionyl)-3a-hydroxy-1,2,3,3a,8,8a-hexahydro-pyrrolo[2,3-b]indole-2-carboxylic acid methyl ester 
• 643751-46-6 3a-hydroxy-2,3,3a,8a-tetrahydro-pyrrolo[2,3-b]indole-1,2,8-tricarboxylic acid 1-benzyl ester 8-tert-butyl ester 2-methyl ester 
• 643751-48-8 3a-hydroxy-3,3a,8,8a-tetrahydro-2H-pyrrolo[2,3-b]indole-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 108431-24-9 (3S,5aS,10bR,11aS)-3-Benzyl-10b-hydroxy-2,3,6,10b,11,11a-hexahydro-5aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole-1,4-dione 
• 643751-44-4 3a-phenylselanyl-2,3,3a,8a-tetrahydro-pyrrolo[2,3-b]indole-1,2,8-tricarboxylic acid 1-benzyl ester 8-tert-butyl ester 2-methyl ester 
• 936336-72-0 N-carbobenzyloxy-1-tert-butoxycarbonyl-L-tryptophanol 

Relevant articles and documents

Method for preparing pharmaceutical intermediate of tryptophan derivative

The synthesis method comprises the following steps: L - tryptophan derivatives are taken as starting materials, and esterification is carried out in sequence. The amidation, Boc protection, hydrolysis, amidation or sequential esterification, amidation, Boc protection, hydrogenation, hydrolysis, amidation yields a target product, a tryptophan derivative pharmaceutical intermediate. The preparation method has the advantages of cheap and easily available raw materials, environment friendliness, less process three wastes, accords with the idea of green pharmacy, mild reaction conditions, simple process, simple and convenient operation, high yield and purity and easy amplification and production.

Copper-catalyzed cyclization of lodo-tryptophans: A straightforward synthesis of pyrroloindoles

(Chemical Equation Presented) Pyrroloindoles are a key structural motif found in a wide number of biologically active alkaloids. Intramolecular copper-catalyzed coupling of readily accessible 2-iodo-tryptophan derivatives occurs in excellent yield, afford