- Synthesis method of ethyl 8-bromocaprylate
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The invention provides a synthesis method of ethyl 8-bromocaprylate, which comprises the following steps: S1, carrying out substitution reaction on 1,6-dibromohexane and diethyl malonate to obtain a compound 2-(6-bromohexyl)-diethyl malonate; S2, enabling the 2-(6-bromohexyl)-diethyl malonate to carry out ester hydrolysis and a decarboxylation reaction so as to obtain 8-bromocaprylic acid; and S3, carrying out an esterification reaction on the 8-bromocaprylic acid and absolute ethyl alcohol to obtain ethyl 8-bromocaprylate. According to the synthesis method of ethyl 8-bromocaprylate, disclosed by the embodiment of the invention, firstly, 1,6-dibromohexane initial raw material and diethyl malonate are subjected to substitution reaction to generate 2-(6-bromohexyl) diethyl malonate, and then ester hydrolysis and decarboxylation reaction are carried out to obtain 8-bromocaprylic acid; and finally,esterification reaction is carried out to generate ethyl 8-bromocaprylate. The raw materials are easy to obtain, side reactions in the reaction are few, the process is simple, and the method is suitable for industrial production, and has a very wide application prospect.
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Paragraph 0060-0063; 0070-0072; 0078-0080; 0085-0087
(2021/07/10)
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- Combating metastasis of breast cancer cells with a carboplatin analogue containing an all-trans retinoic acid ligand
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Pt-ATRA, a carboplatin analogue containing an all-trans retinoic acid (ATRA) derivative ligand, was synthesized via a click reaction. Upon cellular internalization, Pt-ATRA exhibits a dual function, releasing an active Pt(ii) moiety to induce cell apoptosis and ATRA to inhibit tumor metastasis.
- Cheng, Junjie,Dai, Yi,Huang, Hai,Liu, Yangzhong,Shen, Ai-Zong,Zhu, Yang
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supporting information
p. 5039 - 5043
(2020/05/08)
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- The synthesis of new potential photosensitizers. 1. Mono-carboxylic acid derivatives of tetraphenylporphyrin
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A series of mono-alkylcarboxylic acid derivatives of tetraphenylporphyrin have been prepared. All the porphyrins were completely characterized by use of mass, 1H NMR, UV-visible, and fluorescence spectroscopy. Experimental log P were determined
- Zieba, Grzegorz,Rojkiewicz, Marcin,Kozik, Violetta,Jarzembek, Krystyna,Jarczyk, Anna,Sochanik, Aleksander,Kus, Piotr
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experimental part
p. 153 - 159
(2012/06/30)
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- Process for the monoalkylation of C-H acid methylene groups
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The ratio of the alkali(ne earth) carbonate to the methylene group-containing substrate is above 0.6 : 1 in the monoalkylation of C-H acid methylene groups by reaction of the substrate in a polar aprotic solvent with a dihalogen compound having its halogens separated by a chain of at least3C and with reaction being in presence of the alkali(ne earth) carbonates and a phase transfer catalyst and being accompanied by continuous removal of the water formed. An Independent claim is also included for production of omega-haloalkyl-nitriles or -carboxylic acids by reacting a malonic acid diester or cyanoacetic ester with an alpha,omega-dihaloalkane as above and then saponifying and decarboxylating the product.
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Page/Page column 5
(2008/06/13)
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- Thermal properties of liquid-crystalline diols and corresponding bis-urethanes with mesogenic groups of various structures in side chains
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The liquid-crystalline dials with mesogenic groups of different structures were synthetized and their temperature behavior and existence of mesophases were determined. These compounds were also reacted with phenylisocyanate to form bis-urethanes at the ra
- Kaspar,Hamplova,Novotna,Studenovsky,Ilavsky
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- Intramolecular photoreactions of phthalimide-alkene systems. Macrocyclic synthesis through the remote Paterno-Buchi reaction of phthalimide with indole derivatives
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Upon irradiation, phthalimide-indole in bichromophoric systems underwent intramolecularly remote Paterno-Buchi reaction to give oxeto[2,3-b]indole derivatives containing macrocycles, in competition with Norrish type II reaction.
- Takechi,Machida,Nishizono,Kanaoka
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p. 188 - 196
(2007/10/02)
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- Synthese de l'acide (dimercapto-1,3 propyl-2)-15 pentadecanoique, complexant potentiel du 99mTc
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The synthesis of 15-(1,3-dimercapto 2-propyl) pentadecanoic acid was performed in ten steps.One of these steps is the condensation of (5) with 7-bromoheptanoic acid.It is achieved in liquid ammonia or in a HMPA-THF medium with yields higher than 50 percent.In the second case a-5 bromoacid-ratio of 2.1 (slightly superior to the stoichiometry) is sufficient to obtain these yields, whereas in ammonia, the ratio must be higher than 5 and is therefore clearly unfavourable.The reaction times are also much longer in ammonia.The obtention of 5 from diethyl (6-bromohexyl) malonate 2 implies the reduction of ester functions and the substitution of Br by the ethynyl group.The optimal conditions and the sequence of these two steps have been determined.
- Alagui, Abdelhakim,Apparu, Marcel,Comet, Michel,Pasqualini, Roberto,Vidal, Michel
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p. 113 - 117
(2007/10/02)
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- Acides gras marques en position ω par un nucleide radioactif emetteur γ
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The synthesis of many saturated, acetylenic, olefinic (Z or E) fatty acids labeled with 123I or 131I at the ω-position has been achieved.The radioactive iodine atom is introduced by a I-, *I- exchange reaction; the influence on the yield of several parameters - presence of iodine carrier, fatty acid and water concentrations, solution acidity - has been studied.Experimental conditions which produce labeling yields higher than 95percent have been defined; these results have lead to a very easy labeling method used in several hospitals in the external study of myocardial metabolism of fatty acids.
- Riche, Francoise,Mathieu, Jean-Paul,Vincens, Maurice,Bardy, Andre,Comet, Michel,Vidal, Michel
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