- Preparation method of 2, 4, 6-trichlorobenzonitrile
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The invention provides a preparation method of 2, 4, 6-trichlorobenzonitrile. The method comprises the following steps: (1) contacting 1, 3, 5-trichlorobenzene with a bromination reagent in an aprotic solvent to carry out bromination reaction to prepare 2-bromo-1, 3, 5-trichlorobenzene; and (2) enabling the 2-bromo-1, 3, 5-trichlorobenzene to make contact with a cyaniding reagent in a dipolar aprotic solvent to carry out cyaniding reaction so as to prepare the 2, 4, 6-trichlorobenzonitrile. The 1, 3, 5-trichlorobenzene which is low in price and easy to obtain is used as the raw material, the bromination reaction and the cyanidation reaction are sequentially carried out in the specific solvent, the raw material conversion rate is high, and the 2, 4, 6-trichlorobenzonitrile has the advantages of high yield and purity, short route, simple process, low cost, environmental protection and the like.
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Paragraph 0030; 0033-0037; 0040-0041
(2021/06/26)
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- Method for preparing 2, 4, 6-trichlorobenzonitrile by ammonia oxidation method, special catalyst and preparation method
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The invention discloses a method for preparing 2, 4, 6-trichlorobenzonitrile by an ammonia oxidation method. According to the method, 1, 3, 5-trichlorobenzene is taken as a raw material, 2, 4, 6-trichlorobenzyl chloride is obtained under the action of a special chloromethylation catalyst, and then 2, 4, 6-trichlorobenzonitrile is obtained under the action of a special ammoxidation catalyst. The invention further discloses a special catalyst for preparing 2, 4, 6-trichlorobenzonitrile and a preparation method. The special chloromethylation catalyst disclosed by the invention can be used for better catalyzing the reaction of 1, 3, 5-trichlorobenzene chloride and formaldehyde or paraformaldehyde and a chlorine atom donor to efficiently obtain 2, 4, 6-trichlorobenzyl chloride; and the specialammoxidation catalyst can well catalyze the reaction of 2, 4, 6-trichlorobenzyl chloride to obtain 2, 4, 6-trichlorobenzonitrile. The special catalyst disclosed by the invention has the advantages ofhigh activity, high product yield, good selectivity, high product purity, long service life and simple process; the preparation method has the advantages of short reaction route, low reaction temperature, high yield and high selectivity.
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Paragraph 0034-0039
(2020/08/22)
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- Microwave promoted rapid dehydration of aldoximes to nitriles using melamine-formaldehyde resin supported sulphuric acid in dry media
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A simple and convenient procedure for the synthesis of nitriles by dehydration of aldoxime using supported sulphuric acid on melamine-formaldehyde resin (MFR) under solvent-free condition has been developed. A variety of aromatic and aliphatic aldoximes were converted to the corresponding nitriles. The resin was recovered and reused for subsequent reactions.
- Rezaei, Ramin,Karami, Marzeih
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experimental part
p. 815 - 818
(2012/01/06)
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- 1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS
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The present invention relates to compounds of the Formula (I) which are useful for treating conditions associated with mGluR3 receptors, such as depression, schizophrenia and migraine, pharmaceutical compositions thereof, and methods of using the same.
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Page/Page column 73-74
(2010/11/08)
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- Process for producing polychlorobenzonitrile
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A process for producing polychlorobenzonitrile having chlorine atoms at the 2,6-position by ammoxidation of toluene derivative having chlorine atoms at the 2,6-position with a gas containing ammonia and oxygen in vapor phase in the presence of a catalyst, characterized in that bromine and/or a bromine-containing compound is added to the reaction system.
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