- Method for preparing 2, 4, 6-trichlorobenzonitrile by ammonia oxidation method, special catalyst and preparation method
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The invention discloses a method for preparing 2, 4, 6-trichlorobenzonitrile by an ammonia oxidation method. According to the method, 1, 3, 5-trichlorobenzene is taken as a raw material, 2, 4, 6-trichlorobenzyl chloride is obtained under the action of a special chloromethylation catalyst, and then 2, 4, 6-trichlorobenzonitrile is obtained under the action of a special ammoxidation catalyst. The invention further discloses a special catalyst for preparing 2, 4, 6-trichlorobenzonitrile and a preparation method. The special chloromethylation catalyst disclosed by the invention can be used for better catalyzing the reaction of 1, 3, 5-trichlorobenzene chloride and formaldehyde or paraformaldehyde and a chlorine atom donor to efficiently obtain 2, 4, 6-trichlorobenzyl chloride; and the specialammoxidation catalyst can well catalyze the reaction of 2, 4, 6-trichlorobenzyl chloride to obtain 2, 4, 6-trichlorobenzonitrile. The special catalyst disclosed by the invention has the advantages ofhigh activity, high product yield, good selectivity, high product purity, long service life and simple process; the preparation method has the advantages of short reaction route, low reaction temperature, high yield and high selectivity.
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Paragraph 0023-0029
(2020/08/22)
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- Formamides as Lewis Base Catalysts in SNReactions—Efficient Transformation of Alcohols into Chlorides, Amines, and Ethers
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A simple formamide catalyst facilitates the efficient transformation of alcohols into alkyl chlorides with benzoyl chloride as the sole reagent. These nucleophilic substitutions proceed through iminium-activated alcohols as intermediates. The novel method, which can be even performed under solvent-free conditions, is distinguished by an excellent functional group tolerance, scalability (>100 g) and waste-balance (E-factor down to 2). Chiral substrates are converted with excellent levels of stereochemical inversion (99 %→≥95 % ee). In a practical one-pot procedure, the primary formed chlorides can be further transformed into amines, azides, ethers, sulfides, and nitriles. The value of the method was demonstrated in straightforward syntheses of the drugs rac-Clopidogrel and S-Fendiline.
- Huy, Peter H.,Motsch, Sebastian,Kappler, Sarah M.
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supporting information
p. 10145 - 10149
(2016/08/16)
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- PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES
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Compounds of Formula (I) wherein R1 is C1-C4alkyl or C1-C4 haloalkyl; R2 is C1-C4alkyl; R3 is hydrogen or halogen; R4 is hydrogen, C1-C4alkyl or C1-C4halogenalkyl; R5 is hydrogen, halogen, C1-C4alkyl or C1-C4halogenalkyl; R6 is hydrogen, halogen, C1-C4alkyl, C2-C6alkenyl or C3-C6alkinyl; R7 is hydrogen, halogen, C1-C6alkyl, C2-C6alkenyl, C3-C6alkinyl, C3-C6cycloalkyl-C3-C6alkinyl, halophenoxy, halophenyi, C1-C6haloalkyl, C1-C6haloakoxy, C2-C6haloalkenyl, or C2-C6haloalkenyloxy; R8 is hydrogen, halogen, C1-C4alkyl, C2-C6alkenyl or C3-C6alkinyl; with the provisio that at least one of R6, R7 and R8 is different from hydrogen; n is 0 or 1, are suitable for use as microbriocides.
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Paragraph 0166-0169
(2013/03/28)
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- PESTICIDAL COMPOUNDS
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A compound of formula (I) wherein R1 to R4 are, for example, each hydrogen, R5 is, for example, a substituted phenol; R6 is, for example, hydrogen; R7 is, for example, hydrogen, cyano, hydroxyl, formyl, C1 -C4-alkyl, C1 -C4-alkoxy, C2-C4- alkenyl, or C2-C4-alkynyl; and A1 to A5 is, for example, A1 is N or C-X, A3 is C-X, and A2, A4 and A5 are C-H, where X, is, for example, halogen; and its use as a pesticidal agent.
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Page/Page column 90
(2013/05/22)
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- NOVEL PYRAZOLE-4-N-ALKOXYCARBOXAMIDES AS MICROBIOCIDES
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Compounds of formula (I) in which the substituents are as defined in claim 1, are suitable for use as microbiocides.
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Page/Page column 18
(2011/10/10)
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- PYRAZOLECARBOXAMIDE DERIVATIVES AND THEIR USE AS MICROBIOCIDES
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Compounds of Formula (I) wherein R1 is C1-C4alkyl or C1 -C4 haloalkyl; R2 is C1-C4alkyl; R3 is hydrogen or halogen; R4 is hydrogen, C1-C4alkyl or C1-C4halogenalkyl; R5 is hydrogen, halogen, C1-C4alkyl or C1-C4halogenalkyl; R6 is hydrogen, halogen, C1-C4alkyl, C2-C6alkenyl or C3-C6alkinyl; R7 is hydrogen, halogen, C1-C6alkyl, C2-C6alkenyl, C3-C6alkinyl, C3-C6cycloalkyl- C3-C6alkinyl, halophenoxy, halophenyi, C1-C6haloalkyl,C1-C6haloakoxy, C2- C6haloalkenyl, or C2-C6haloalkenyloxy; R8 is hydrogen, halogen, C1-C4alkyl, C2-C6alkenyl or C3-C6alkinyl; with the provisio that at least one of R6, R7 and R8 is different from hydrogen; n is 0 or 1, are suitable for use as microbriocides.
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Page/Page column 34
(2011/12/14)
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- NOVEL MICROBIOCIDES
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Compounds of formula (I) in which the substituents are as defined in claim 1,are suitable for use as microbiocides.
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Page/Page column 41
(2010/06/20)
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- NOVEL MICROBIOCIDES
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Compounds of formula I (I) in which the substituents are as defined in claim 1, are suitable for use as microbiocides.
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Page/Page column 26
(2009/12/02)
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