Trifluoromethylation of 1-aryl-3,3-diisopropyltriazenes
A new method for the trifluoromethylation of functionalized aromatic diisopropyltriazenes is described. In a facile two-step, one-pot synthesis, various functionalized trifluoromethyl-substituted arenes are accessible in mostly good yields by using methyl iodide as iodination agent and the trifluoromethylation system (trifluoromethyl)trimethylsilane/potassium fluoride/copper iodide. This concept could be expanded to perfluoroethylation as well as ethoxycarbonyldifluoromethylation reactions. Copyright
Hafner, Andreas,Braese, Stefan
supporting information
p. 996 - 1000
(2013/05/08)
Trifluoromethyl substituted 1-aminoindanes
4(5 or 6 or 7)-Trifluoromethyl-1-aminoindanes, useful as inhibitors of N-methyl transferase.
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(2008/06/13)
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