H-D exchange reaction taking advantage of the synergistic effect of heterogeneous palladium and platinum mixed catalyst
An effective and applicable deuteration method for alkyl-substituted aromatic compounds using a heterogeneous Pd/C and Pt/C mixed catalyst in deuterium oxide in the presence of a small amount of hydrogen gas was developed. Mixing a heterogeneous palladium
General method of obtaining deuterium-labeled heterocyclic compounds using neutral D2O with heterogeneous Pd/C
A protocol of a versatile H-D exchange reaction of heterocyclic compounds catalyzed by heterogeneous Pd/C in D2O is described. The reaction of various nitrogen-containing heterocycles with 10% Pd/C (10 wt % of the substrate) under hydrogen atmosphere in D2O as a deuterium source at 110-180 °C for 24 h afforded the corresponding deuterated compounds with satisfactory efficiency of deuteration in moderate to excellent isolated yields. Furthermore, the Pd/C-H2-D2O system can be extended to the direct deuteration of biologically active compounds such as sulfamethazine, which is used as a synthetic antibacterial drug for fat stocks and would be applied as a general method for the preparation of the standard materials for the analysis of residual chemicals in foods and so on.
"DEUTERATED" RANEY NICKEL: DEUTERATION (REDUCTION) OF ALKENES, CARBONYL COMPOUNDS AND AROMATIC RINGS. PROTON-DEUTERIUM EXCHANGE OF "ACTIVATED" ALIPHATIC AND AROMATIC RING HYDROGENS.
In the absence of deuterium gas, the reaction of deuterated Raney nickel with benzene derivatives, carbonyl compounds, alkenes and activated methylene grops gave either fully deuterated (reduced) products or led to hydrogen-deuterium exchange.
Pojer, Peter M.
p. 2507 - 2508
(2007/10/02)
More Articles about upstream products of 66148-15-0