- The first efficient biocatalytic route for the synthesis of Kojic acid derivatives in aqueous media
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The first efficient biocatalytic route for the synthesis of kojic acid derivatives was developed in presence of an enzyme. In this process, benzaldehydes, malononitrile and kojic acid were used as starting materials while lipase from Aspergillus niger was
- Dalal, Kiran S.,Chaudhari, Mangal A.,Dalal, Dipak S.,Chaudhari, Bhushan L.
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- MCM-41-SO3H: an efficient, reusable, heterogeneous catalyst for the one-pot, three-component synthesis of pyrano[3,2-b]pyrans
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MCM-41-SO3H, ordered mesoporous silica material MCM-41 with covalently anchored sulfonic acid groups, was used as a solid acid catalyst for the convenient, efficient, and ‘green’ synthesis of 2-amino-6-(hydroxymethyl)-8-oxo-4-aryl-4,8-dihydropy
- Sarrafi, Yaghoub,Mehrasbi, Ebrahim,Mashalchi, Seyyedeh Zohreh
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p. 1729 - 1741
(2021/04/02)
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- Acetic Acid-Mediated Synthesis of Kojic Acid Derivatives
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Abstract: A green acetic acid-mediated synthesis of kojic acid derivatives through amulticomponent reaction (MCR) has been developed. This new protocol is simpleand efficient; it involves a one-pot reaction of equimolar amounts of kojicacid, aromatic alde
- Barbosa, L. C. A.,Kiran, Y. B.,Rambabu, G.,Vijayakumar, V.
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p. 1158 - 1166
(2021/09/08)
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- Synthesis and biological assessment of KojoTacrines as new agents for Alzheimer’s disease therapy
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In view of the multifactorial nature of Alzheimer’s disease (AD), multitarget small molecules (MTSM) represent the most potent and attractive therapeutic strategy to design new drugs for Alzheimer’s disease therapy. The new MTSM KojoTacrines (KTs) were designed and synthesized by juxtaposition of selected pharmacophoric motifs from kojic acid and tacrine. Among them, 11-amino-2-(hydroxymethyl)-12-(3-methoxyphenyl)-7,9,10,12-tetrahydropyrano [2',3':5,6] pyrano[2,3-b]quinolin-4(8H)-one (KT2d) was identified as less-hepatotoxic than tacrine, at higher concentration, a moderate, but selective human acetylcholinesterase inhibitor (IC50 = 4.52 ± 0.24 μM), as well as an antioxidant agent (TE = 4.79) showing significant neuroprotection against Aβ1–40 at 3 μM and 10 μM concentrations. Consequently, KT2d is a potential new hit-ligand for AD therapy for further biological exploration.
- Dgachi, Youssef,Martin, Hélène,Malek, Rim,Jun, Daniel,Janockova, Jana,Sepsova, Vendula,Soukup, Ondrej,Iriepa, Isabel,Moraleda, Ignacio,Maalej, Emna,Carreiras, M. Carmo,Refouvelet, Bernard,Chabchoub, Fakher,Marco-Contelles, José,Ismaili, Lhassane
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p. 163 - 170
(2019/01/03)
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- One-pot synthesis of 2-amino-4,8-dihydropyrano[3,2-b]pyranes and pyridopyrimidines under mild conditions
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1,8-Diazabicyclo[5.4.0]undec-7-ene immobilized on silica (SB-DBU)Cl as a reusable and heterogeneous catalyst was applied for the one-pot, three-component synthesis of 2-amino-4,8-dihydropyrano[3,2-b]pyrane-3-carbonitriles and pyridopyrimidines, under solvent-free conditions. The reaction was carried out at room temperature, and pure products were obtained in high yields and short reaction times (3–7 min). This work introduced an environmentally benign procedure for the synthesis of these classes of biological active compounds.
- Rigi, Fatemeh,Shaterian, Hamid Reza
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p. 434 - 437
(2018/10/26)
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- Microwave-assisted, water-mediated Michael addition for synthesis of kojic acid derivatives
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A highly efficient method is described for the synthesis of substituted kojic acid derivatives in the presence of water under microwave irradiation. This transformation represents an efficient way to synthesize kojic acid derivatives from simple starting
- Likhar, Pravin R.,Reddy, G. Narshimha,Reddy, M. Ramana
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p. 5983 - 5989
(2016/06/01)
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- Supramolecular catalysis by β-cyclodextrin for the synthesis of kojic acid derivatives in water
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An efficient and green method has been developed for the synthesis of kojic acid derivatives by employing 20 mol% β-cyclodextrin in aqueous media. The high functional group tolerance and shorter reaction times make this method suitable for the synthesis o
- Kataev, Evgeny A.,Ramana Reddy, Mittapalli,Niranjan Reddy, Gangarpu,Reddy, Vemulapati Hanuman,Suresh Reddy, Cirandur,Subba Reddy, Basi V.
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p. 1693 - 1697
(2016/02/19)
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- An efficient three-component synthesis of amino-substituted pyrano[3,2-b] pyranones
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A green, efficient and mild one-pot synthesis of pyrano[3,2-b]pyran derivatives via a three component reaction in the ionic liquid [bmim]BF 4 is reported. This method has the advantages of environmental friendliness, operational simplicity, high yields and reuse of the ionic liquid.
- Meng, Xiang-Xue,Du, Bai-Xiang,Zhao, Bo,Li, Yu-Ling,Chen, Cai-Fa
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p. 638 - 641
(2013/11/06)
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