- 2-trifluoromethylpyrimidin-4-carboxylic acid and its derivatives and preparation method thereof
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The invention relates to 2-trifluoromethylpyrimidin-4-carboxylic acid with a general formula (I) and its derivatives. In the general formula (I), R represents COOH, COOX, COORn, COOCH3, COOCH2CH3 or CH2OH, X represents any alkali or amine which can react with a strong acid or carboxylic acid to produce a salt and Rn represents any carbonyl compound. The invention also relates to a preparation method of the compound. The preparation method has good controllability, mainly solves the technical problem of large-scale production limitation and has a good application prospect.
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Paragraph 0033; 0034
(2017/05/23)
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- LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS
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Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.
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Paragraph 0544
(2013/03/26)
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- MODULATORS OF CXCR7
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Compounds having formula (I) or pharmaceutically acceptable salts, hydrates or N-oxides thereof are provided and are useful for binding to CXCR7, and treating diseases that are dependent, at least in part, on CXCR7 activity. Accordingly, the present inven
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Page/Page column 59
(2010/06/11)
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- SYNTHESIS OF 2-ARYL PYRIMIDINE 4-CARBOXYLIC ACID AMIDES
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Disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4 substituted 2-oxo-3-butenyl amide. Also disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid ami
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- Alkadiene derivatives, their preparation, and pharmaceutical compositions containing them
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Substituted alkadienes of the formula: STR1 in which R1 is hydroxy or acetoxy, R2 is hydrogen, carboxy, alkoxycarbonyl, phenyl or benzoyl, and R3 is alkylthio or alkoxy and R4 is naphthoyl or optionally substituted benzoyl, or R3 is alkoxycarbonyl, cycloalkyloxycarbonyl or cyano and R4 is alkyl, naphthyl, optionally substituted phenyl, alkylthio, naphthylmethanethio, optionally substituted benzylthio, optionally substituted phenylthio, naphthylthio, phenethylthio or allylthio, or R3 and R4 form, with the carbon atom to which they are attached, a ring-system of formula: STR2 in which R5 is hydrogen or alkoxy and X is methylene or S inhibit 5-lipoxygenase and are useful, for example, as anti-inflammatories.
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