67751-14-8

Basic information

• Product Name: ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE
• Synonyms: ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE;ETHYL(3E)-3-(ISOPROPYLIMINO)-2-OXOPROPANOATE;4-Dimethylamino-2-oxo-but-3-enoic acid ethyl ester;3-Butenoic acid, 4-(dimethylamino)-2-oxo-, ethyl ester;Ethyl (E)-4-(dimethylamino)-2-oxo-but-3-enoate;-2-oxobut-3-enoate;Ethyl 4-(dimethylamino);ethyl (3E)-4-(dimethylamino)-2-oxobut-3-enoate
• CAS NO: 67751-14-8
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.19
• Product Categories: Aliphatics;Esters
• Mol File: 67751-14-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 38 °C
• Boiling Point: 180 °C
• Flash Point: 92.3 °C
• Appearance: /
• Density: 1.056 g/cm³
• Vapor Pressure: 0.0709mmHg at 25°C
• Refractive Index: 1.463
• PKA: 6.03±0.70(Predicted)
• CAS DataBase Reference: ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE(67751-14-8)
• EPA Substance Registry System: ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE(67751-14-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 67751-14-8(Hazardous Substances Data)

Usage

General Description

ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE is a chemical compound with the molecular formula C8H13NO3. It is an ester derivative of 2-oxobut-3-enoic acid. ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE is commonly used in organic synthesis as a reagent for the preparation of various pharmaceutical and research chemicals. It is also used as a precursor for the synthesis of other important organic compounds. ETHYL 4-(DIMETHYLAMINO)-2-OXOBUT-3-ENOATE is a colorless liquid with a slightly fruity odor, and it is considered to be relatively stable under normal storage conditions.

InChI:InChI=1/C8H13NO3/c1-4-12-8(11)7(10)5-6-9(2)3/h5-6H,4H2,1-3H3/b6-5+

Upstream product

• 617-35-6 2-oxo-propionic acid ethyl ester 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 
• 122831-02-1 t-butyl 4-dimethylamino-2-oxo-3-butenoate 
• 76849-54-2 t-butyl pyruvate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 361436-79-5 2-[4-(4-chloro-2-fluorophenoxy)phenyl]pyrimidine-4-carboxamide 
• 253769-50-5 ethyl 2-phenylpyrimidine-4-carboxylate 
• 250726-39-7 ethyl-2-methylsulfanylpyrimidine-4-carboxylate 
• 115342-26-2 ethyl 1–(4-bromophenyl)-1H-pyrazole-5-carboxylate 
• 1423701-76-1 C₂₄H₂₄N₂O₄ 
• 5932-27-4 ethyl 1H-pyrazole-3-carboxylate 
• 1185016-32-3 ethyl 2-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenylamino]-pyrimidine-4-carboxylate 
• 67750-78-1 C₁₆H₁₈N₂O₂ 
• 122831-18-9 diethyl 2-(dimethylamino)-5-(benzylthio)-2,4-hexadienedioate 
• 129363-78-6 ethyl 2-(dimethylamino)-6-phenyl-6-oxo-5-(phenylthio)-2,4-hexadienoate 
• 122831-03-2 (2E,4Z)-2-Dimethylamino-5-phenylsulfanyl-hexa-2,4-dienedioic acid diethyl ester 
• 122830-59-5 (2Z,4E)-2-Benzylsulfanyl-5-hydroxy-hexa-2,4-dienedioic acid diethyl ester 
• 129363-79-7 diethyl 5-benzoyl-2-(dimethylamino)-2,4-hexadienedioate 

Relevant articles and documents

Synthesis of 2-(β-D-ribofuranosyl)pyrimidines, a new class of C-nucleosides

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LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the lysophosphatidic acid receptors are provided.

SYNTHESIS OF 2-ARYL PYRIMIDINE 4-CARBOXYLIC ACID AMIDES

Disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid amides by reacting an aryl carboxamidine with a 4 substituted 2-oxo-3-butenyl amide. Also disclosed is a method for the preparation of 2-aryl pyrimidine 4 carboxylic acid ami