Synthesis and structure-activity relationships of novel warfarin derivatives
4-Hydroxycoumarins such as warfarin 1 have been the mainstay of oral anticoagulation therapy for over 20 years. Yet little detail is known about the molecular interactions between 4-hydroxycoumarins with vitamin K epoxide reductase (VKER), inhibition of w
Gebauer, Markus
p. 2414 - 2420
(2007/10/03)
The reactivity of 4-hydroxycoumarin under heterogeneous high-intensity sonochemical conditions
High-intensity ultrasounds have been employed in the synthesis of 4-hydroxycoumarin derivatives, using mainly water as reaction medium. Marked improvements of reaction rates, chemoselectivity and product yields have been observed on comparing sonochemical with ordinary conditions. In the alkylation of a series of allyl and benzyl bromides a pathway switch occured to yield 3-alkyl-4-hydroxycoumarin derivatives.
Cravotto, Giancarlo,Nano, Gian Mario,Palmisano, Giovanni,Tagliapietra, Silvia
p. 1286 - 1291
(2007/10/03)
A regioselective synthesis of 3-isoprenyl-4-hydroxycoumarins
The dianion of ethyl 3-(2-hydroxyphenyl)-3-oxopropanoate can be regioselectively alkylated with isoprenyl bromides to give, after hydrolytic work-up, the corresponding 3-substituted-4-hydroxycoumarins.
Appendino,Cravotto,Nano,Palmisano
p. 2205 - 2212
(2007/10/02)
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