6805-34-1 Usage
Uses
Ferulenol is antibiotic useful against mycobacteria similar to taxol.
Biological Activity
ferulenol is a prenylated 4-hydroxycoumarin derivative from ferula communis var. genuine with haemorrhagic action [1]. it has been demonstrated that ferulenol exihibits potent antimycobacterial activity [2].
in vitro
ferulenol stimulated tubulin polymerization in the absence of gtp, with a less extensive polymerization profile at 100 pm concentration. ferulenol decreased radiolabeled colchicine bound by tubulin in a dose-dependent manner. ferulenol altered the normal nuclear morphology of mcf-7 cells. treatment with ferulenol (100 nm and 1 μm) for 24h induced a dose-dependent reduction of cell viability [3]
in vivo
in albino mice, the acute ld50s of ferulenol by single po or ip were 2,100 and 319 mg/kg bw, respectively. three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages. male mice were more sensitive to intoxication than females [4].
references
[1] lamnaouer d, bodo b, martin m t, et al. ferulenol and ω-hydroxyferulenol, toxic coumarins from ferula communis var. genuina[j]. phytochemistry, 1987, 26(6): 1613-1615.[2] e. mamoci, i. cavoski, v. simone, et al. chemical composition and in vitro activity of plant extracts from ferula communis and dittrichia viscosa against postharvest fungi. molecules 16(3), 2609-2625 (2011).[3] bocca c, gabriel l, bozzo f, et al. microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol[j]. planta medica, 2002, 68(12): 1135-1137.[4] fraigui o, lamnaouer d, faouzi m y. acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from ferula communis l[j]. veterinary and human toxicology, 2002, 44(1): 5-7.
Check Digit Verification of cas no
The CAS Registry Mumber 6805-34-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,0 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 6805-34:
(6*6)+(5*8)+(4*0)+(3*5)+(2*3)+(1*4)=101
101 % 10 = 1
So 6805-34-1 is a valid CAS Registry Number.
InChI:InChI=1/C24H30O3/c1-17(2)9-7-10-18(3)11-8-12-19(4)15-16-21-23(25)20-13-5-6-14-22(20)27-24(21)26/h5-6,9,11,13-15,26H,7-8,10,12,16H2,1-4H3/b18-11+,19-15+
6805-34-1Relevant articles and documents
Synthesis and structure-activity relationships of novel warfarin derivatives
Gebauer, Markus
, p. 2414 - 2420 (2007/10/03)
4-Hydroxycoumarins such as warfarin 1 have been the mainstay of oral anticoagulation therapy for over 20 years. Yet little detail is known about the molecular interactions between 4-hydroxycoumarins with vitamin K epoxide reductase (VKER), inhibition of w
A regioselective synthesis of 3-isoprenyl-4-hydroxycoumarins
Appendino,Cravotto,Nano,Palmisano
, p. 2205 - 2212 (2007/10/02)
The dianion of ethyl 3-(2-hydroxyphenyl)-3-oxopropanoate can be regioselectively alkylated with isoprenyl bromides to give, after hydrolytic work-up, the corresponding 3-substituted-4-hydroxycoumarins.
