Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including huma
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Page/Page column 19; 22
(2008/06/13)
REARRANGED PENTANOLS, A METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE AS ANTIPHLOGISTICS
The invention relates to compounds of formula (I), to a method for the production thereof, and to their use as antiphlogistics.
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Page/Page column 32
(2008/06/13)
Rearranged pentanols, a process for their production and their use as anti-inflammatory agents
The invention relates to the compounds of formula I, a process for their production and their use as anti-inflammatory agents.
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Page/Page column 12
(2010/02/12)
2-Nitroimidazol-5-ylmethyl as a potential bioreductively activated prodrug system: Reductively triggered release of the parp inhibitor 5- bromoisoquinolinone
5-Chloromethyl-1-methyl-2-nitroimidazole reacted efficiently with the anion derived from 5-bromoisoquinolin-1-one to give 5-bromo-2-((1-methyl-2- nitroimidazol-5-yl)methyl)isoquinolin-1-one. Biomimetic reduction effected release of the 5-bromoisoquinolin-1-one. The 2-nitroimidazol-5-ylmethyl unit thus has potential for development as a general prodrug system for selective drug delivery to hypoxic tissues.
Parveen, Ifat,Naughton, Declan P.,Whish, William J. D.,Threadgill, Michael D.
p. 2031 - 2036
(2007/10/03)
The chemistry of indoles. XII. A facile route to 5-nitroisocoumarins and methyl indole-4-carboxylate
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Somei,Karasawa,Shoda,Kaneko
p. 249 - 253
(2007/10/02)
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