- Semi-shelled melon ring C containing aniline structure33 H39 O3 N9 Synthesis method and synthesis method thereof
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The invention discloses a semi-melon ring C containing an aniline structure. 33 H39 O3 N9 , The C33 H39 O3 N Chemistry name 35 , 75 , 115 - Triamino -1 , 5, 9 (1, 3) - triazoline generation -3 , 7, 11 (1, 3) - triphenyl cyclododecatriene -12 , 52 , 92 ; Trione. C33 H39 O3 N9 The synthesis method of 5 -nitrobenzene -1, 3 - diacid-AONS-3,5 - bis - (bromomethyl) nitrobenzene-AOE286928692X0AO_ 3,5 bis (- 1,3 - (bromomethyl) -5 - 3 - 3,5 - nitrobenzene 3 -2 -) imidazoli -2 -AOE286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869286928692869 5 . 5 , 75 , 115 - Trinitro -1 , 5, 9 (1, 3) - triazoline generation -3 , 7, 11 (1, 3) - triphenyl cyclododecatriene -12 , 52 , 92 - Triketone-AOE 286928692X0AO_ 35 , 75 , 115 - Triamino -1 , 5, 9 (1, 3) - triazoline generation -3 , 7, 11 (1, 3) - triphenyl cyclododecatriene -12 , 52 , 92 ; Trione. C33 H39 O3 N9 Can regard as Fe3 + A detector; and a detector. The utility model can also be used as a detector for nitrophenol substances. The synthesis method has the characteristics of simplicity, rapidness, easiness in operation, low cost and the like.
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Paragraph 0032; 0055-0056; 0077-0078; 0083-0084; 0089-0090
(2021/10/27)
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- AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES
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The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.
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Page/Page column 20-21; 45-47; 52
(2020/10/20)
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- Exploring London Dispersion and Solvent Interactions at Alkyl–Alkyl Interfaces Using Azobenzene Switches
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Interactions on the molecular level control structure as well as function. Especially interfaces between innocent alkyl groups are hardly studied although they are of great importance in larger systems. Herein, London dispersion in conjunction with solvent interactions between linear alkyl chains was examined with an azobenzene-based experimental setup. Alkyl chains in all meta positions of the azobenzene core were systematically elongated, and the change in rate for the thermally induced Z→E isomerization in n-decane was determined. The stability of the Z-isomer increased with longer chains and reached a maximum for n-butyl groups. Further elongation led to faster isomerization. The origin of the intramolecular interactions was elaborated by various techniques, including 1H NOESY NMR spectroscopy. The results indicate that there are additional long-range interactions between n-alkyl chains with the opposite phenyl core in the Z-state. These interactions are most likely dominated by attractive London dispersion. This work provides rare insight into the stabilizing contributions of highly flexible groups in an intra- as well as an intermolecular setting.
- Strauss, Marcel A.,Wegner, Hermann A.
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supporting information
p. 18552 - 18556
(2019/11/19)
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- A Cyclic-RGD Dinuclear TbIII Macrocyclic Complex as a Tumor Integrin-Selective Luminescent Probe
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To develop small molecular integrin-selective luminescent imaging probes, we have prepared the binary dipicolinate (DPA) TbIII dinuclear macrocyclic complex, Tb2(cRGDfK-ODO2A-dimer) (DPA)22– or complex I, and reference ligands and TbIII complexes which were purified by HPLC and characterized by NMR, mass spectrometry and luminescence spectroscopy. Luminescence titrations of the structural and bonding model Tb2(m-ODO2A-dimer)2+ complex by DPA2– ion confirmed the molecular formula of the adduct was Tb2(m-ODO2A-dimer)(DPA)22–, and the first binary binding constant was determined to be log K1 = 5.76. At pH 7.4, complex I showed 300 times luminescence enhancement at 544 nm (λex = 278 nm) as compared to that without adding DPA, and was found to bind to αvβ3 integrin and human glioblastoma U87MG tumor cells in both specific and non-specific modes, via luminescence spectroscopic and confocal cell imaging competition studies. This makes complex I and its future optimized derivatives potentially feasible for preclinical bioimaging applications, particularly in the time-resolved mode.
- Chang, C. Allen,Chia, Ju-Chien,Lin, Syue-Liang
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p. 3270 - 3279
(2018/07/31)
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- Liquid-Crystalline Star-Shaped Supergelator Exhibiting Aggregation-Induced Blue Light Emission
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A family of closely related star-shaped stilbene-based molecules containing an amide linkage are synthesized, and their self-assembly in liquid-crystalline and gel states was investigated. The number and position of the peripheral alkyl tails were systematically varied to understand the structure-property relation. Interestingly, one of the molecules with seven peripheral chains was bimesomorphic, exhibiting columnar hexagonal and columnar rectangular phases, whereas the rest of them stabilized the room-temperature columnar hexagonal phase. The self-assembly of these molecules in liquid-crystalline and organogel states is extremely sensitive to the position and number of alkoxy tails in the periphery. Two of the compounds with six and seven peripheral tails exhibited supergelation behavior in long-chain hydrocarbon solvents. One of these compounds with seven alkyl chains was investigated further, and it has shown higher stability and moldability in the gel state. The xerogel of the same compound was characterized with the help of extensive microscopic and X-ray diffraction studies. The nanofibers in the xerogel are found to consist of molecules arranged in a lamellar fashion. Furthermore, this compound shows very weak emission in solution but an aggregation-induced emission property in the gel state. Considering the dearth of solid-state blue-light-emitting organic materials, this molecular design is promising where the self-assembly and emission in the aggregated state can be preserved. The nonsymmetric design lowers the phase-transition temperatures.The presence of an amide bond helps to stabilize columnar packing over a long range because of its polarity and intermolecular hydrogen bonding in addition to promoting organogelation.
- Pathak, Suraj Kumar,Pradhan, Balaram,Gupta, Monika,Pal, Santanu Kumar,Sudhakar, Achalkumar Ammathnadu
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p. 9301 - 9312
(2016/10/06)
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- A phosphonic acid appended naphthalene diimide motif for self-assembly into tunable nanostructures through molecular recognition with arginine in water
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A naphthalene diimide motif bearing phosphonic acid functionalities has been found to be self-assembled with l- and d-arginine through chirality induced molecular recognitions and leads to the formation of micrometre long nanobelts and spherical aggregates at pH 9 in water, respectively.
- Nandre, Kamalakar P.,Bhosale, Sheshanath V.,Rama Krishna,Gupta, Akhil,Bhosale, Sidhanath V.
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supporting information
p. 5444 - 5446
(2013/06/27)
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- Caged CO2 for the Direct Observation of CO2-Consuming Reactions
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CO2-consuming reactions, in particular carboxylations, play important roles in technical processes and in nature. Their kinetic behavior and the reaction mechanisms of carboxylating enzymes are difficult to study because CO2 is inconvenient to handle as a gas, exists in equilibrium with bicarbonate in aqueous solution, and typically yields products that show no significant spectroscopic differences from the reactants in the UV/Vis range. Here we demonstrate the utility of 3-nitrophenylacetic acid and related compounds (caged CO2) in conjunction with infrared spectroscopy as widely applicable tools for the investigation of such reactions, permitting convenient measurement of the kinetics of CO2 consumption. The use of isotopically labeled caged CO2 provides a tool for the assignment of infrared absorption bands, thus aiding insight into reaction intermediates and mechanisms.
- Lommel, Katharina,Sch?fer, Gabriela,Grenader, Konstantin,Ruland, Christoph,Terfort, Andreas,M?ntele, Werner,Wille, Georg
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p. 372 - 380
(2013/08/24)
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- Synthesis and evaluation of bifunctional chelating agents derived from bis(2-aminophenylthio)alkane for radioimaging with 99mTc
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Novel bifunctional chelating agents bearing an aromatic rigid backbone have been synthesized and characterized on the basis of spectroscopic techniques. These macrocyclic multidentate chelating agents were conjugated with monoclonal antibody which forms stable complexes with 99mTc with high radiochemical purity.
- Chhikara, Bhupender S.,Kumar, Nitin,Tandon, Vibha,Mishra, Anil K.
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p. 4713 - 4720
(2007/10/03)
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- An expedient approach to internally functionalized chiral dendrimers: Synthesis of a dendritic molecule incorporating furanoside skeleton
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In an approach to chiral dendritic molecules, a dendrimer incorporating pentose units in the interior and hexose units in the periphery is built up on a 1, 3, 5-trisubstituted aromatic core by using 1,2:5,6-diisopropylidene glucose as the carbohydrate precursor and a 3, 5-disubstituted aromatic unit as the branching block. The carbohydrate moiety also provides internal functionalities in the form of hemiacetal moiety of the furanoside ring.
- Ghorai, Subir,Bhattacharjya, Anup,Basak, Ajoy,Mitra, Abhijit,Williamson, R. Thomas
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p. 617 - 620
(2007/10/03)
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- Electron Donor-Acceptor Compounds, XXXVIII. Electron Donor-Acceptor Metacyclophanes: Synthesis, Structure, and Charge-Transfer Spectra
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Donor-acceptor metacyclophanes 1-4 as well as 24 were synthesized via the correspondingly substituted 2,11-dithiametacyclophanes 8, 13, and 25 and their disulfone derivatives.The anti-compound 1 and the syn-isomer 2 were isolated and characterized.The attempt of the analogous synthesis of 5/6 via 21 and 22 failed since with loss of the intraanular substituents and by transanular C-C formation the tetrahydropyrene derivative 23 was formed.For spectroscopic comparison 27 was prepared via 28.- X-Ray structure analyses of 21, 24, and 25 were performed.The molecular structures of these compounds are discussed under the aspects of sterical strain and donor-acceptor overlap.The structure analyses confirm the assignment to the syn- and anti-series as derived from 1H NMR.- Absorption spectra of 1, 2, 3, and 24 were measured; especially the surprising absorption behaviour of the isomers 1 and 2 with very different donor-acceptor overlap was of interest.Determination of the solvent dependence of fluorescence made sure that the absorptions dealt with are indeed charge-transfer transitions.
- Staab, Heinz A.,Schanne, Lothar,Krieger, Claus,Taglieber, Volker
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p. 1204 - 1229
(2007/10/02)
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