Electroanalysis of 10-bromo-11b-(2-fluorophenyl-one)-2,3,7,1b-tetrahydrooxazolo [3,2][1,4]-benzodiazepin-6-(5H) (Haloxazolam)
Sulfuric acid (2.7 m) with 10% (vol.) ethylene glycol dimethylether provides sufficient stability of the electroactive form of haloxalozam (1) and may be used as a supporting electrolyte for its DCP or DPP determination in pharmaceutical preparations. The polarographic behaviour of 1 was investigated: the polarographic curves are markedly influenced by the hydrolysis of the original inactive form 1 to the iminium species A and further to the substituted benzophenone B in which both heterocyclic rings have been opened. The mechanism and the kinetics of these hydrolytic reactions have been studied and an interpretation has been suggested. The recommended determination is based on the 2-electron reduction of A. The lower sensitivity limit is 2.5·10-5 mol·l-1 in the DC mode and 2.5·10-6 mol·l-1 in DPP. In the analysis of single tablets the relative standard deviation S(rel) is 1.8 for 5 mg and 3.8 for 10 mg tablets (both DCP). Therefore, this polarographic method is suitable for the content uniformity test.
Volke,Oelschlager
p. 824 - 828
(2007/10/02)
The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of flutazolam and haloxazolam in aqueous solution
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Kuwayama,Kurono,Muramatsu,Yashiro,Ikeda
p. 320 - 326
(2007/10/02)
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