- Synthesis, Characterization and Antimicrobial Activity of Bis(Phthalimido)Piperazine and its Derivatives: a New Class of Bioactive Molecules with Enhanced Safety and Efficacy
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Piperazine rings are important heterocyclic targets in organic synthesis and are useful synthetic intermediates or intricate parts of biologically active molecules. In our efforts, a series of piperazine derivatives has been prepared discovering new classes of antimicrobial agents, including bis(phthalimido)piperazine, bis(3-aminopropyl) piperazine, 2,3-dihydro-phthalazine-1,4-dione, and bis(3,4-aminophenol)piperazine. The synthesized antimicrobial agents have been studied using various spectroscopic techniques. Furthermore, these compounds have been screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Three compounds exhibited mild to good antibacterial activity, but somewhat lower antifungal activity against tested microbial strains.
- Aslam, Afeefa,Abbas, Muhammad Azhar,Iqbal, Mudassir,Bashir, Sajid,Mehmood, Tahir,Kressler, Joerg
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- The unexpected conversion of 1,5,8,12-tetraazadodecane-glyoxal bisaminal into its amidinium salt in an acidic medium
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When refluxed in aqueous hydrochloric acid solution, 1,5,8,12-tetraazadodecane-glyoxal bisaminal is quantitatively converted into its amidinium salt, which is a lactam precursor. The mechanism of this unexpected reaction is discussed. Wiley-VCH Verlag GmbH & Co, KGaA, 69451 Weinheim, Germany, 2003.
- Bernard, Helene,Del Rio Garcia, Eugenia,Ferec, Sonia,Kervarec, Nelly,Handel, Henri
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- PREPARING METHOD OF SOLID CARBAMIC ACID DERIVATIVES
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The present disclosure relates to a preparation method for powder of a carbamic acid derivative, which includes reacting a liquid amine derivative with carbon dioxide at a temperature in a range of from about ?30° C. to about 500° C. at a pressure in a range of from about 0.3 MPa to about 100 MPa. In addition, the present disclosure relates to a reduction method for powder of a carbamic acid derivative to a liquid amine derivative and carbon dioxide, which includes dissolving powder of the carbamic acid derivative prepared in a solvent; refluxing the carbamic acid derivative at a temperature in a range of from about 30° C. to about 100° C.; and evaporating the solvent. The preparation method for a carbamic acid derivative powder according to the present disclosure enables easy conversion into pure powder of solid carbamic acid derivative without by-products and can remarkably reduce time and energy required for solidification by reacting carbon dioxides and amines with carbon dioxides in high pressure conditions without the use of a solvent. In addition, the prepared solid compounds can be used as a liquid amine substitute or used in a carbamic acid derivative form as necessary.
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Paragraph 0081-0082
(2014/03/24)
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- DIHYDROPYRIMIDONE MULTIMERS AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS
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A compound of formula M-L-M (I) wherein L is a linker and each M is independently a group of formula (II) is useful in therapy, e.g. of respiratory diseases.
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Page/Page column 31
(2008/06/13)
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- MULTIMERS OF HETEROCYCLIC COMPOUNDS AND THEIR USE
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A compound of formula (I): M-L-M, wherein L is a linker and each M is independently a group of formula (II): is useful in therapy, e.g. of respiratory diseases.
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Page/Page column 78
(2008/06/13)
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- Bis-aminals of linear tetraamines: Kinetic and thermodynamic aspects of the condensation reaction
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The kinetic and thermodynamic aspects of the condensation reaction of dicarbonyl compounds with linear tetraamines were examined in the light of identification of intermediates and DFT calculations. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, German
- Chuburu, Francoise,Tripier, Raphael,Le Baccon, Michel,Handel, Henri
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p. 1050 - 1055
(2007/10/03)
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- Poly-bis-triazinylimides, their preparation
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Poly-bis-triazinylimides of the formula STR1 are prepared from bis-(2,4-dichloro-1,3,5-triazin-6-yl)imides and polyalkylpiperidylamines. They are used as light stabilizers for polymers.
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