7209-38-3

Basic information

• Product Name: 1,4-Bis(3-aminopropyl)piperazine
• Synonyms: 1,4-Piperazinedipropanamine;3-[4-(3-Aminopropyl)-1-piperazinyl]propylamine;N,N'-Bis(p-aminopropyl)piperazine;Piperazine, 1,4-bis(3-aminopropyl)-;1,4-DI(3-AMINOPROPYL)PIPERAZINE;1,4-BIS(3-AMINOPROPYL)PIPERAZINE;1,4-(BIS AMINOPROPYL) PIPERAZINE;1,4-PIPERAZINEBIS(PROPYLAMINE)
• CAS NO: 7209-38-3
• Molecular Formula: C₁₀H₂₄N₄
• Molecular Weight: 200.32
• EINECS: 230-589-1
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Piperazines;B;Bioactive Small Molecules;Building Blocks;C10;Cell Biology;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 7209-38-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 15 °C(lit.)
• Boiling Point: 150-152 °C2 mm Hg(lit.)
• Flash Point: 325 °F
• Appearance: colorless to yellow liquid
• Density: 0.973 g/mL at 25 °C(lit.)
• Vapor Density: 6.9 (vs air)
• Vapor Pressure: 0.133Pa at 25℃
• Refractive Index: n20/D 1.502(lit.)
• PKA: 10.69±0.10(Predicted)
• Water Solubility: Fully miscible in water.
• Sensitive: Air Sensitive
• BRN: 111747
• CAS DataBase Reference: 1,4-Bis(3-aminopropyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Bis(3-aminopropyl)piperazine(7209-38-3)
• EPA Substance Registry System: 1,4-Bis(3-aminopropyl)piperazine(7209-38-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• RTECS: TK8700000
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 7209-38-3(Hazardous Substances Data)

Usage

Chemical Properties

colorless to yellow liquid

Uses

1,4-Bis(3-aminopropyl)piperazine was used to functionalize natural montmorillonite (M) and synthetic kanemite (K)1.

General Description

The thermodynamic parameters for protonation of 1,4-bis(3-aminopropyl)-piperazine (BAPP) were studied in aqueous solution using a potentiometric technique.

Safety Profile

Poison by intravenous route. Acorrosive material and a powerful irritant to skin, eyes, andmucous membranes. When heated to decomposition itemits toxic fumes of NOx.

Upstream product

• 110-85-0 piperazine 
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• 131543-46-9 Glyoxal 
• 10563-26-5 N,N'-bis(3-aminopropyl)-1,2-diamine 
• 679426-37-0 3-(4-(4-(carboxyamino)propyl)piperazin-1-yl)propan-1-amine 
• 86689-13-6 N,N'-bis<3-<(tert-butyloxycarbonyl)amino>propyl>piperazine 

Downstream Products

• 54945-23-2 6,12-dioxo-1,5,13,17,22-penta-azatricyclo-<15.2.2.1^7,11>docosa-7(22),8,10-triene 
• 86745-96-2 1,4-bis<3-(2,4,5-trichlorophenoxyacetamido)propyl>piperazine 
• 4425-82-5 9-methylene-fluorene 
• 106-47-8 4-chloro-aniline 
• 86758-80-7 2-(2,4,6-Trimethyl-phenoxy)-N-[3-(4-{3-[2-(2,4,6-trimethyl-phenoxy)-acetylamino]-propyl}-piperazin-1-yl)-propyl]-acetamide; hydrochloride 
• 86746-09-0 2-(4-Bromo-3,5-dimethyl-phenoxy)-N-[3-(4-{3-[2-(4-bromo-3,5-dimethyl-phenoxy)-acetylamino]-propyl}-piperazin-1-yl)-propyl]-acetamide 
• 76094-07-0 N,N’-bis[(2-hydroxybenzylideneamino)-propyl]-piperazine 
• 76131-56-1 ((C₆H₃OHCl)CHN(CH₂)3)2C₄H₈N₂ 
• 74861-79-3 {3-[4(3-amino-propyl)-piperazin-1-yl]-propyl}-(9-methoxy-5-methyl-6H-pyrido[4,3-b]carbazol-1-yl)-amine 
• 76094-08-1 N,N'-bis(2-hydroxy-5-bromobenzyl)-1,4-bis(3-iminopropyl)piperazine 
• 240429-17-8 {3-[4-(3-amino-propyl)-piperazin-1-yl]-propyl}-cyclohexylmethyl-amine 
• 58943-43-4 1,4-bis-[3-(4-chloro-benzylideneamino)-propyl]-piperazine 

Relevant articles and documents

Synthesis, Characterization and Antimicrobial Activity of Bis(Phthalimido)Piperazine and its Derivatives: a New Class of Bioactive Molecules with Enhanced Safety and Efficacy

Piperazine rings are important heterocyclic targets in organic synthesis and are useful synthetic intermediates or intricate parts of biologically active molecules. In our efforts, a series of piperazine derivatives has been prepared discovering new classes of antimicrobial agents, including bis(phthalimido)piperazine, bis(3-aminopropyl) piperazine, 2,3-dihydro-phthalazine-1,4-dione, and bis(3,4-aminophenol)piperazine. The synthesized antimicrobial agents have been studied using various spectroscopic techniques. Furthermore, these compounds have been screened for their in vitro antimicrobial activity against selected bacterial and fungal strains. Three compounds exhibited mild to good antibacterial activity, but somewhat lower antifungal activity against tested microbial strains.

PREPARING METHOD OF SOLID CARBAMIC ACID DERIVATIVES

The present disclosure relates to a preparation method for powder of a carbamic acid derivative, which includes reacting a liquid amine derivative with carbon dioxide at a temperature in a range of from about ?30° C. to about 500° C. at a pressure in a range of from about 0.3 MPa to about 100 MPa. In addition, the present disclosure relates to a reduction method for powder of a carbamic acid derivative to a liquid amine derivative and carbon dioxide, which includes dissolving powder of the carbamic acid derivative prepared in a solvent; refluxing the carbamic acid derivative at a temperature in a range of from about 30° C. to about 100° C.; and evaporating the solvent. The preparation method for a carbamic acid derivative powder according to the present disclosure enables easy conversion into pure powder of solid carbamic acid derivative without by-products and can remarkably reduce time and energy required for solidification by reacting carbon dioxides and amines with carbon dioxides in high pressure conditions without the use of a solvent. In addition, the prepared solid compounds can be used as a liquid amine substitute or used in a carbamic acid derivative form as necessary.

DIHYDROPYRIMIDONE MULTIMERS AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS

A compound of formula M-L-M (I) wherein L is a linker and each M is independently a group of formula (II) is useful in therapy, e.g. of respiratory diseases.