NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND IN COSMETICS
The invention relates to novel heterocyclic compounds of general formula (I), as well as their pharmaceutically acceptable salts, and their enantiomers. The invention also relates to the use thereof as a medicinal product, preferably in the prevention and/or treatment of inflammatory diseases with a neurogenic component or use thereof as a cosmetic. The compounds of the present invention act as antagonists of the CGRP-R receptor.
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Paragraph 1158
(2018/03/25)
Vicarious Nucleophilic Substitution of Hydrogen in Nitroarenes with α-Substituted Nitriles and Esters. Direct α-Cyanoalkylation and α-Carbalkoxyalkylation of Nitroarenes
Carbanions generated from alkanenitriles bearing α-chloro, α-OR, or α-SR groups and from aliphatic esters bearing α-SR groups react with mononitroarenes to replace hydrogen atoms of the nitroaromatic ring ortho or para to the nitro group with α-cyanoalkyl or α-carbalkoxyalkyl substituents.The nucleophilic replacement of hydrogen with such carbanions proceeds faster than substitution of halogen ortho or para to the nitro group.
Makosza, Mieczyslaw,Winiarski, Jerzy
p. 1494 - 1499
(2007/10/02)
Vicarious Substitution of Hydrogen in Aromatic Nitro Compounds with Acetonitrile Derivatives
Carbanions of α-phenoxy and thioalkoxy nitriles substitute hydrogen in the para or ortho position of aromatic nitro compounds, giving nitroarylacetonitriles in a process in which phenolate or thiolate anions are vicarious leaving groups.
Makosza, Mieczyslaw,Winiarski, Jerzy
p. 1534 - 1535
(2007/10/02)
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