72301-70-3

Basic information

• Product Name: α-<2-Nitro-5-(methylthio)phenyl>acetonitrile
• Synonyms: α-<2-Nitro-5-(methylthio)phenyl>acetonitrile
• CAS NO: 72301-70-3
• Molecular Weight: 208.241
• Mol File: 72301-70-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: α-<2-Nitro-5-(methylthio)phenyl>acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: α-<2-Nitro-5-(methylthio)phenyl>acetonitrile(72301-70-3)
• EPA Substance Registry System: α-<2-Nitro-5-(methylthio)phenyl>acetonitrile(72301-70-3)

Safety Data

• Hazardous Substances Data: 72301-70-3(Hazardous Substances Data)

Upstream product

• 701-57-5 1-methylthio-4-nitro-benzene 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 
• 61540-35-0 S-(Dimethylthiocarbamoyl)thioglycolonitrile 
• 35120-10-6 methylthioacetonitrile 

Relevant articles and documents

NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF IN MEDICINE AND IN COSMETICS

The invention relates to novel heterocyclic compounds of general formula (I), as well as their pharmaceutically acceptable salts, and their enantiomers. The invention also relates to the use thereof as a medicinal product, preferably in the prevention and/or treatment of inflammatory diseases with a neurogenic component or use thereof as a cosmetic. The compounds of the present invention act as antagonists of the CGRP-R receptor.

Vicarious Substitution of Hydrogen in Aromatic Nitro Compounds with Acetonitrile Derivatives

Carbanions of α-phenoxy and thioalkoxy nitriles substitute hydrogen in the para or ortho position of aromatic nitro compounds, giving nitroarylacetonitriles in a process in which phenolate or thiolate anions are vicarious leaving groups.