- Therapeutically Active Thiazolo-Pyrimidine Derivatives
-
A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
- -
-
Paragraph 0290
(2014/10/29)
-
- THERAPEUTICALLY ACTIVE THIAZOLO-PYRIMIDINE DERIVATIVES
-
A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.
- -
-
Page/Page column 57
(2013/05/23)
-
- Heterocyclic cyclopropyl-substituted FXR binding compounds
-
The present invention relates to compounds defined by formula (I): or an enantiomer, diastereomer, tautomer, solvate or pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently from each other selected from hydro
- -
-
Page/Page column 20-21
(2009/12/23)
-
- Heterocyclic FXR binding compounds
-
The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
- -
-
Page/Page column 26
(2008/06/13)
-
- COMPOUNDS AS CRF1 RECEPTOR ANTAGONISTS
-
The present invention relates to compounds of Formula I,or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compounds of the inventions are CRF, receptor antagonists. Compounds of the invention are useful for t
- -
-
-
- HETEROARYL- SUBSTITUTED PYRROLO` 2, 3- B! PYRIDINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS
-
The present invention provides compounds of formula (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts or solvates thereof, to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of conditions mediated by corticotropin-releasing factor (CRF).
- -
-
Page/Page column 35
(2010/02/07)
-
- CRF ligands via Suzuki and Negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine.
-
A series of imidazo[4,5-b]pyridines with a 7-(3-pyridyl) substituent is described as high affinity CRF receptor ligands. Individual analogues were synthesized from key intermediates obtained via palladium-catalyzed coupling of 3-pyridyl zinc or boronic acid organometallic intermediates with 2-benzyloxy-4-chloro-3-nitropyridine 12.
- Arvanitis, Argyrios G,Arnold, Charles R,Fitzgerald, Lawrence W,Frietze, William E,Olson, Richard E,Gilligan, Paul J,Robertson, David W
-
p. 289 - 291
(2007/10/03)
-