- 2, 6-DISUBSTITUTED PYRIDINES AND 2, 4-DISUBSTITUTED PYRIMIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS
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Disclosed are compounds of formula (I): wherein n represents 1 or 2; each R1 independently represents halo or trifluoromethyl; wherein halo represents fluoro, chloro or bromo; R2 represents hydrogen or C1-3alkyl; X represents N or CH; wherein -Z- represents a group selected from: (A), (B) or (C), wherein R3 represents trifluoromethyl or C1-3alkyl; and R4 represents hydrogen, trifluoromethyl or C1-3alkyl; with the proviso that where Z represents a thiophene group and X represents N, R2 cannot represent C1-3alkyl; and when X represents CH, -Z- can additionally represent a group selected from: (D) or (E) or salts thereof which activate soluble guanylate cyclase (sGC) pharmaceutical compositions containing them, their use is medicine, and processes for their preparation.
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Page/Page column 24
(2009/07/03)
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- An efficient and easy route to trimethyl derivatives of 2,2':6',2''-terpyridine
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By using the Stille coupling reaction, trimethyl derivatives of 2,2':6',2''-terpyridine have been prepared in good yields.
- Fallahpour
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p. 1665 - 1667
(2007/10/03)
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- Herbicidal heterocyclic-substituted pyridines
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The present invention relates to 2,6-substituted pyridines of formula I, their preparation and use as herbicides.
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- Herbicidal 2,6-substituted pyridines
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A herbicidal composition which comprises at least one carrier and, as active ingredient, a compound of the general formula STR1 in which each of n and m independently is 0 or 1; each of Ar1 and Ar2 independently is an aryl group, at least one of Ar1 and Ar2 being substituted by one or more of the same or different substituents selected from halogen atoms, alkyl groups, alkoxy groups, haloalkyl groups and haloalkoxy groups; and R1 is hydrogen, or an alkyl, alkylthio or haloalkyl group having from 1 to 4 carbon atoms, and R2 is hydrogen or a halogen atom provided that at least one of R1 and R2 represents a hydrogen atom. Certain compounds of formula I are novel.
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