Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood-brain barrier after intravenous dosing
Poitout, Lydie,Brault, Valerie,Sackur, Carole,Bernetiere, Sonia,Camara, Jose,Plas, Pascale,Roubert, Pierre
p. 4464 - 4470
(2008/03/11)
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