746662-01-1Relevant articles and documents
Identification of a novel series of benzimidazoles as potent and selective antagonists of the human melanocortin-4 receptor
Poitout, Lydie,Brault, Valerie,Sackur, Carole,Bernetiere, Sonia,Camara, Jose,Plas, Pascale,Roubert, Pierre
, p. 4464 - 4470 (2008/03/11)
A novel series of benzimidazoles was identified and optimized, leading to the discovery of potent and selective antagonists of the human melanocortin-4 receptor. In addition, compound 5i was shown to cross the blood-brain barrier after intravenous dosing