cas 75-55-8, 2-Methylaziridine | Articles data

Articles about 75-55-8Total 10 be found

Synthetic method of aromatic aziridine cross-linking agent
The invention discloses a synthetic method of an aromatic aziridine cross-linking agent (figure 1). The method comprises three chemical synthesis steps: (I) reacting 1-amino-2-propanol with chlorosulfonic acid to obtain amino-isopropyl sulfate; (II) carrying out an intra-molecular nucleophilic substitution reaction on amino-isopropyl sulfate in alkali liquor, removing sulfate radical groups, and carrying out ring closing to generate an intermediate 2-methyl aziridine; and (III) directly reacting the obtained 2-methyl aziridine with isophthaloyl dichloride in a mixed system of alkali liquor andan organic solvent without separation, and carrying out separation and purification to obtain a final product 1,1'-(1,3-phthaloyl)bis(2-methyl-aziridine). The commodity name is HX-752, and the aromatic aziridine cross-linking agent has wide application. A liquid-liquid homogeneous or heterogeneous reaction is adopted, the reaction conditions are mild, the process is simple and easy to control, and the yield is high. Besides, the synthesis method has the advantages of fewer byproducts and low waste discharge amount, is suitable for large-scale production, and has favorable industrialization prospects.
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Paragraph 0039-0047

(2020/12/08)

Preparation method of 2-methylaziridine
The invention belongs to the field of chemical synthesis, and particularly relates to a preparation method of 2-methylaziridine. The 2-methylaziridine is synthesized from isopropanolamine, sulfuric acid and liquid caustic soda as raw materials, the synthesis condition is mild, and mass industrial production is facilitated. Besides, the synthesis materials are simple, sulfate esterification and liquid caustic soda hydrolysis are adopted, caustic soda flakes are used for purification in the distillation and purification process, few byproducts are produced, and the method is green and environmentally friendly; initial distillation under normal pressure and fine distillation under low pressure are adopted, and the obtained 2-methylaziridine has the purity of 99% or above.
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Paragraph 0024; 0035-0036; 0038; 0048-0049; 0050; 0061-0062

(2019/07/29)

CATALYST FOR SYNTHESIZING ETHYLENIMINE AS WELL AS PREPARATION METHOD AND APPLICATION THEREOF
The present invention relates to a catalyst for synthesizing ethylenimine as well as a preparation method and application thereof. The related catalyst comprises a carrier and metal ions loaded on the carrier; the carrier is a composite oxide comprising titanium, silicon and phosphorus elements; the metal ions are magnesium ions, iron ions and cesium ions; the molar ratio of the magnesium ions to the iron ions to the cesium ions is (1-10):1:0.1; the mass of all metal ions is 0.5-10 percent of that of the carrier. In the related preparation method, a catalyst precursor is roasted at the temperature of 350-650° C., so that the catalyst is obtained; the catalyst precursor is the mixture of the carrier, soluble salt of magnesium, soluble salt of iron and soluble salt of cesium. The present invention also provides the application of the catalyst to synthesis of the ethylenimine by using amino alcohol as the raw material. Compared with a common catalyst which has the requirement on the temperature of over 400° C., the catalyst of the present invention obviously reduces the reaction temperature. The prepared catalyst can catalyze the intramolecular dehydration reaction of the amino alcohol and has relatively excellent selectivity.
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Paragraph 0042

(2016/11/17)

An improved and mild wenker synthesis of aziridines
The conventional Wenker synthesis of aziridines from vicinal amino alcohols has been modified by employing mild reaction conditions. Amino alcohols were converted into their hydrogen sulfates with chlorosulfonic acid. The sulfates were cyclized with sodium hydroxide, and even with non-nucleophilic sodium carbonate. The current, improved method extends the scope of the typical Wenker synthesis and is applicable to unstable amino alcohols in hot sulfuric acid and to unstable sulfates which favor elimination and hydroxide displacement in the presence of strong base. Georg Thieme Verlag Stuttgart.
Li, Xinyao,Chen, Ning,Xu, Jiaxi
experimental part
p. 3423 - 3428
(2010/11/21)

Scavenger assisted combinatorial process for preparing libraries of amides, carbamates and sulfonamides
This invention relates to a novel solution phase process for the preparation of amide, carbamate, and sulfonamide combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.
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(2008/06/13)

Efficient Optical Resolution of Aziridines with Optically active host compounds
Some aziridines are resolved efficiently by complexation with optically active host compounds which were derived from tartaric acid.
Mori, Koji,Toda, Fumio
p. 281 - 282
(2007/10/02)

Aziridino containing nitro imidazoles and pharmaceutical compositions
A compound of formula I STR1 in which formula: R1 represents hydrogen or an alkyl group; R2 -R5 represent hydrogen, alkyl aryl, aralkyl or alkaryl group; and n is 1.
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(2008/06/13)

Cyclodehydration of N- and C-Substituted β-Amino Alcohols to the Corresponding Aziridines with Diethoxytriphenylphosphorane
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Kelly, Jeffery W.,Eskew, Nita L.,Evans, Slayton A.
p. 95 - 97
(2007/10/02)

CATALYTIC SYNTHESIS OF DIAZINES FROM 1,3-DIAMINOPROPANE AND 3-AMINO-1-PROPANOL
The transformation of 1,3-diaminopropane and 3-amino-1-propanol under pulse conditions over tungsten trioxide in an inert atmosphere at 300-500 deg C were investigated.The transformation of 1,3-diaminopropane leads to the formation of saturated pyrimidine
Oshis, Ya. F.,Anderson, A. A.,Shimanskaya, M. V.
p. 740 - 745
(2007/10/02)