- Chemical transformations on botryane skeleton. Effect on the cytotoxic activity
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Eighteen compounds with a botryane skeleton have been obtained through chemical transformations of various toxins from the fungus Botrytis cinerea. During the course of these transformations, the C-10 carbon of the botryane skeleton was found to exhibit an interesting high regioselectivity to oxidizing and reducing agents. In addition, the cytotoxicity of 27 botryane derivatives was determined in vitro against Hs578T, MDA-MB-231, HT-1080, U87-MG, IMR-90, and HUVEC cell lines. The results of this study confirm that the cytotoxicity of botrydial (1) and its derivatives is related to the presence of a 1,5-dialdehyde functionality.
- Reino, Jose L.,Duran-Patron, Rosa,Segura, Inmaculada,Hernandez-Galan, Rosario,Riese, Hans H.,Collado, Isidro G.
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p. 344 - 349
(2007/10/03)
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- Three New Sesquiterpenoid Metabolites of Botrytis cinerea
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The C-15 carboxylic acid corresponding to botrydial and its C-4 alcohol, together with the C-10 carboxylic acid related to dihydrobotrydial, have been isolated from Botrytis cinerea.They have been inter-related with dihydrobotrydial.
- Bradshaw, A. Peter W.,Hanson, James R.
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p. 741 - 743
(2007/10/02)
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