cas 756525-99-2, alpha-MaleiMidopropionyl-oMega-succiniMidyl-4(ethylene glycol) | Articles data ｜lookchem

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756525-99-2

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Antibody drug conjugate, intermediate, preparation method, pharmaceutical composition and uses thereof
Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.
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(2019/11/11)

ANTI-FOLATE RECEPTOR APLHA (FRA) ANTIBODY-DRUG CONJUGATES AND METHODS OF USING THEREOF
The present disclosure provides anti-folate receptor alpha (FRA) antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.
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(2016/06/28)

ANTI-CD22 ANTIBODY-DRUG CONJUGATES AND METHODS OF USING THEREOF
The present disclosure provides anti-CD22 antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.
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Paragraph 0273; 0281

(2016/05/09)

HYDROPHILIC SELF-IMMOLATIVE LINKERS AND CONJUGATES THEREOF
The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a hydrophilic group to provide better solubility of the compound. The compounds of the present disclosure comprise a drug moiety, a targeting moiety capable of targeting a selected cell population, and a linker which contains an acyl unit, an optional spacer unit for providing distance between the drug moiety and the targeting moiety, a peptide linker which can be cleavable under appropriate conditions, a hydrophilic self-immolative linker, and an optional second self-immolative spacer or cyclization self-elimination linker.
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Paragraph 240; 248

(2014/07/08)

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Chemical Properties

Density: 1.36±0.1 g/cm3(Predicted)
Storage Temp.:?20°C
PKA: 15.01±0.46(Predicted)
PSA: 170.57000
LogP: -0.80250

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